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Review
. 2017 Jul 1;25(4):345-353.
doi: 10.4062/biomolther.2016.126.

Production of Recombinant Anti-Cancer Vaccines in Plants

Jeong Hwan Lee  1 , Kisung Ko  1
Affiliations
Review

Production of Recombinant Anti-Cancer Vaccines in Plants

Jeong Hwan Lee et al. Biomol Ther (Seoul). .

Abstract

Plant expression systems have been developed to produce anti-cancer vaccines. Plants have several advantages as bioreactors for the production of subunit vaccines: they are considered safe, and may be used to produce recombinant proteins at low production cost. However, several technical issues hinder large-scale production of anti-cancer vaccines in plants. The present review covers design strategies to enhance the immunogenicity and therapeutic potency of anti-cancer vaccines, methods to increase vaccine-expressing plant biomass, and challenges facing the production of anti-cancer vaccines in plants. Specifically, the issues such as low expression levels and plant-specific glycosylation are described, along with their potential solutions.

Keywords: Cancer; Glycosylation; Plant expression system; Recombinant protein; Subunit vaccine; Vaccine.

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Conflict of interest statement

CONFLICT OF INTEREST

The authors confirm that they have no conflicts of interest.

Figures

Fig. 1.
Fig. 1.
Plant N-glycosylation pathway and its profile of cancer vaccine expressed in plants. (A) Glycosylation processing pathway in plant (modified from Jamal et al., 2009). (B) The comparative amount of plant-derived colorectal cancer antigen GA733-FcK protein expression level and the ratio of Golgi/endoplasmic reticulum-type glycans along with growth periods (modified from Lim et al., 2015).
See this image and copyright information in PMC

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