New Symptomatic Treatments for the Management of Motor and Nonmotor Symptoms of Parkinson's Disease

Abstract

Motor symptoms are core features of Parkinson's disease, while nonmotor symptoms are present from the prodromal stage. Management strategies for the motor symptoms of Parkinson's disease have been widely researched and there have been many advances. Therapy has evolved from oral therapy to once a day to nonoral strategies, both for rescue and for infusion therapy. Treatment for nonmotor symptoms, however, has remained a key unmet need, although of late evidence base for management of some nonmotor symptoms such as pain, dementia, aspects of sleep dysfunction, and constipation has emerged. However, management of many nonmotor symptoms such as anxiety, apathy, fatigue, and insomnia remains uncharted. In this review, we address these management strategies and discuss the evidence base of available therapies.

Keywords: Dopamine replacement therapy; Motor and nonmotor symptoms; Nondopaminergic; Parkinson's disease.