Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1988 Sep;69(3):187-92.
doi: 10.1016/0041-3879(88)90020-7.

Comparative in vitro and in vivo activity of rifabutin and rifampicin against Mycobacterium avium complex

H Saito  1 , K Sato, H Tomioka
Affiliations
Comparative Study

Comparative in vitro and in vivo activity of rifabutin and rifampicin against Mycobacterium avium complex

H Saito et al. Tubercle. 1988 Sep.

Abstract

In vitro antimicrobial activity of rifabutin and rifampicin against various mycobacteria, including the Mycobacterium avium complex, was evaluated by the agar dilution method, using 7H10 agar medium. The activity of rifabutin based on MIC50 and MIC90 was higher than that of rifampicin, against all the acid-fast organisms tested. Microbicidal activity of rifabutin against the M. avium complex phagocytosed in mouse peritoneal or alveolar macrophages was greater than that of rifampicin. Both rifabutin and rifampicin had therapeutic effects against murine infections induced by M. avium complex. Rifabutin was somewhat more effective than rifampicin in mice.

PubMed Disclaimer

Publication types