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Review
. 2017 May 27;22(6):885.
doi: 10.3390/molecules22060885.

Cellular and Molecular Targets of Resveratrol on Lymphoma and Leukemia Cells

Affiliations
Review

Cellular and Molecular Targets of Resveratrol on Lymphoma and Leukemia Cells

Raffaele Frazzi et al. Molecules. .

Abstract

Resveratrol (RSV) is a well known chemopreventive molecule featuring anti-cancer properties. Our paper describes the main molecular targets of RSV linked to its antiproliferative activity on lymphoma and leukemia experimental models. It discusses further the most recent and most promising among these molecular targets for a translational application.

Keywords: leukemia; lymphoma; molecular target; resveratrol.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Representation of the main molecular targets demonstrated in lymphoma cells. The blunt-ended arrows represent a downregulating effect. Black, up-oriented arrows indicate up-regulation. Red, down-oriented arrows indicate downregulation.
Figure 2
Figure 2
Overview of the main molecular targets demonstrated in leukemia cells.

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References

    1. Latruffe N., Lancon A., Frazzi R., Aires V., Delmas D., Michaille J.J., Djouadi F., Bastin J., Cherkaoui-Malki M. Exploring new ways of regulation by Resveratrol involving miRNAs, with emphasis on inflammation. Ann. N. Y. Acad. Sci. 2015;1348:97–106. doi: 10.1111/nyas.12819. - DOI - PubMed
    1. Lancon A., Frazzi R., Latruffe N. Anti-Oxidant, Anti-Inflammatory and Anti-Angiogenic Properties of Resveratrol in Ocular Diseases. Molecules. 2016;21:304. doi: 10.3390/molecules21030304. - DOI - PMC - PubMed
    1. Jang M., Cai L., Udeani G.O., Slowing K.V., Thomas C.F., Beecher C.W., Fong H.H., Farnsworth N.R., Kinghorn A.D., Mehta R.G., et al. Cancer chemopreventive activity of Resveratrol, a natural product derived from grapes. Science. 1997;275:218–220. doi: 10.1126/science.275.5297.218. - DOI - PubMed
    1. Gusman J., Malonne H., Atassi G. A reappraisal of the potential chemopreventive and chemotherapeutic properties of Resveratrol. Carcinogenesis. 2001;22:1111–1117. doi: 10.1093/carcin/22.8.1111. - DOI - PubMed
    1. Chakraborty P.K., Mustafi S.B., Ganguly S., Chatterjee M., Raha S. Resveratrol induces apoptosis in K562 (chronic myelogenous leukemia) cells by targeting a key survival protein, heat shock protein 70. Cancer Sci. 2008;99:1109–1116. doi: 10.1111/j.1349-7006.2008.00809.x. - DOI - PMC - PubMed