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. 2017:2017:8045161.
doi: 10.1155/2017/8045161. Epub 2017 May 7.

The Distribution of Activation Markers and Selectins on Peripheral T Lymphocytes in Preeclampsia

Anna Bajnok  1 , Maria Ivanova  2 , János Rigó Jr  1 , Gergely Toldi  1
Affiliations

The Distribution of Activation Markers and Selectins on Peripheral T Lymphocytes in Preeclampsia

Anna Bajnok et al. Mediators Inflamm. 2017.

Abstract

Introduction: Impaired maternal immune tolerance resulting in systemic inflammation plays a pivotal role in the pathogenesis of preeclampsia. Phenotypical changes of monocytes and neutrophil granulocytes have already been studied in preeclampsia, and some studies also included T lymphocyte activation markers; however, the results are controversial and a comprehensive analysis of activation markers is lacking. The characteristics of cellular adhesion molecules in preeclampsia are yet to be described.

Material and methods: Peripheral blood samples of 18 preeclamptic patients and 20 healthy pregnant women in the third trimester were evaluated using flow cytometry to characterize the cell surface expression of T lymphocyte activation markers and selectins.

Results: We found an elevated ratio of HLA-DR and CD122-, CD62E-, and CD62L-expressing cells among the CD4+ T lymphocytes in PE in comparison to healthy pregnancy. No alterations were found in the prevalence of CD69-, CD25-, and CD62P-expressing lymphocytes and CD11c-expressing monocytes.

Conclusions: Our findings support the role of activated T lymphocytes and specific cell adhesion molecules in the pathogenesis of preeclampsia.

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Figures

Figure 1
Figure 1
Box plots representing the frequency of the investigated cell subsets in healthy pregnancy (control) and preeclampsia (PE). Horizontal line: median; box: interquartile range (25–75 percentile); whisker: range. ∗p < 0.05 versus control.
See this image and copyright information in PMC

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