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Review
. 2017 May 15:4:26.
doi: 10.3389/fsurg.2017.00026. eCollection 2017.

Why Do Parotid Pleomorphic Adenomas Recur? A Systematic Review of Pathological and Surgical Variables

Pavel Dulguerov  1 , Jelena Todic  1 , Marc Pusztaszeri  2 , Naif H Alotaibi  1
Affiliations
Review

Why Do Parotid Pleomorphic Adenomas Recur? A Systematic Review of Pathological and Surgical Variables

Pavel Dulguerov et al. Front Surg. .

Abstract

Background: The recurrence of pleomorphic adenoma (PA) has been extensively debated, mostly in relation to the extent of parotidectomy.

Methods: A systematic review was undertaken to clarify the surgical and pathological variables related to PA recurrence. Inclusion criteria were as follows: English literature, and prospective or retrospective studies. Exclusion criteria were as follows: single case reports, reviews, and lack of PA recurrence data.

Results: Pathology-related variables associated with recurrence include the histological subtype, the thickness and incompleteness of the tumor capsule, pseudopodia, and satellite nodules. Surgery-related variables associated with recurrence are the presence of intact margins and tumor puncture or spillage. Other factors are the size of the tumor and the age of patient. Myxoid subtypes of PA tend to have incomplete and thinner capsules and to recur more frequently. Surgical variables related to recurrence include positive margins and tumor spillage.

Conclusion: Myxoid and/or large PA, especially in young patients, should be approached more cautiously to avoid recurrences.

Keywords: parotid tumors; parotidectomy; pathology; pleomorphic adenoma; recurrence.

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Figures

Figure 1
Figure 1
Histological subtypes of pleomorphic adenoma. (A) Classic type, (B) myxoid type, and (C) hypercellular type.
Figure 2
Figure 2
Integrity of the pleomorphic adenoma capsule. (A) Capsular integrity preserved and (B) ruptured capsula.
Figure 3
Figure 3
Pseudopodia.
Figure 4
Figure 4
Satellite nodules.
See this image and copyright information in PMC

References

    1. Eveson JW, Cawson RA. Salivary gland tumours. A review of 2410 cases with particular reference to histological types, site, age and sex distribution. J Pathol (1985) 146(1):51–8.10.1002/path.1711460106 - DOI - PubMed
    1. Spiro RH. Salivary neoplasms: overview of a 35-year experience with 2,807 patients. Head Neck Surg (1986) 8(3):177–84.10.1002/hed.2890080309 - DOI - PubMed
    1. Quer M, Guntinas-Lichius O, Marchal F, Vander Poorten V, Chevalier D, Leon X, et al. Classification of parotidectomies: a proposal of the European Salivary Gland Society. Eur Arch Otorhinolaryngol (2016) 273(10):3307–12.10.1007/s00405-016-3916-6 - DOI - PubMed
    1. Witt RL. The significance of the margin in parotid surgery for pleomorphic adenoma. Laryngoscope (2002) 112(12):2141–54.10.1097/00005537-200212000-00004 - DOI - PubMed
    1. Benedict EG, Meigs JV. Tumors of the parotid gland. A study of 225 cases with complete end-results in 80 cases. Surg Gynecol Obstet (1930) 51:626–47.

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