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. 2017 Nov;108(6).
doi: 10.1002/bip.23032.

Activity of synthetic peptides against Chlamydia

Manuela Donati  1 , Giovanna Cenacchi  2 , Roberta Biondi  1 , Valentina Papa  2 , Nicole Borel  3 , Edoardo Vecchio Nepita  1 , Simone Magnino  4 , Gianandrea Pasquinelli  2 , Aurora Levi  1 , Octavio L Franco  5   6
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Free article

Activity of synthetic peptides against Chlamydia

Manuela Donati et al. Biopolymers. 2017 Nov.
Free article

Abstract

The in vitro activity of six synthetic peptides against 36 strains of Chlamydia from different origins was investigated. Clavanin MO (CMO) proved to be the most active peptide, reducing the inclusion number of all Chlamydia strains from eight different species tested by ≥50% at 10 µg mL-1 . Mastoparan L showed an equal activity against C. trachomatis, C. pneumoniae, C. suis, and C. muridarum, but did not exert any inhibitory effect against C. psittaci, C. pecorum, C. abortus, and C. avium even at 80 µg mL-1 . These data suggest that CMO could be a promising compound in the prevention and treatment of chlamydial infections.

Keywords: antimicrobial; chlamydia; immunofluorescence; peptides.

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