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. 2017 Jun 16;82(12):6163-6171.
doi: 10.1021/acs.joc.7b00752. Epub 2017 Jun 7.

Copper-Catalyzed Cross-Dehydrogenative N2-Coupling of NH-1,2,3-Triazoles with N,N -Dialkylamides: N-Amidoalkylation of NH-1,2,3-Triazoles

Xiaocong Deng  1 , Xue Lei  1 , Gang Nie  1 , Lihui Jia  1 , Yuanxiang Li  2 , Yunfeng Chen  1
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Copper-Catalyzed Cross-Dehydrogenative N2-Coupling of NH-1,2,3-Triazoles with N,N -Dialkylamides: N-Amidoalkylation of NH-1,2,3-Triazoles

Xiaocong Deng et al. J Org Chem. .

Abstract

An efficient copper-catalyzed C-N bond formation by N-H/C-H cross-dehydrogenative coupling (CDC) between NH-1,2,3-triazoles and N,N-dialkylamides has been developed. The method provided N-amidoalkylated 1,2,3-triazoles with moderate to high yields, and the reactions showed high N2-selectivities when 4,5-disubstituted NH-1,2,3-triazoles served as the substrates.

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