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Review
. 2017 Jun:38:134-140.
doi: 10.1016/j.cbpa.2017.04.019. Epub 2017 May 27.

Blood-brain barrier peptide shuttles

Macarena Sánchez-Navarro  1 , Ernest Giralt  2 , Meritxell Teixidó  3
Affiliations
Review

Blood-brain barrier peptide shuttles

Macarena Sánchez-Navarro et al. Curr Opin Chem Biol. 2017 Jun.

Abstract

Brain delivery is hampered by the presence of the blood-brain barrier (BBB), a natural defence of the brain that protects it and allows the entrance of nutrients by several mechanisms. Taking advantage of these mechanisms is an opportunity to treat brain related diseases. Among the different alternatives, BBB peptide shuttles are gaining attention to increase brain delivery of therapeutics. The most recent advances in the field are analysed here.

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