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Observational Study
. 2017 Jul 25;61(8):e00228-17.
doi: 10.1128/AAC.00228-17. Print 2017 Aug.

Prevalence of Invasive Infections Due to Carbapenem-Resistant Enterobacteriaceae among Adult Patients in U.S. Hospitals

Thomas Lodise  1 , Michael J Ye  2 , Qi Zhao  2
Affiliations
Observational Study

Prevalence of Invasive Infections Due to Carbapenem-Resistant Enterobacteriaceae among Adult Patients in U.S. Hospitals

Thomas Lodise et al. Antimicrob Agents Chemother. .

Abstract

This large-scale retrospective analysis (n = 60,551) of the Premier inpatient database (1 January 2011 to 31 December 2014) found an overall prevalence of carbapenem-resistant Enterobacteriaceae strains of 2.3% (range, 0.9% to 5.8% by geographic region) among patients with infections due to Enterobacteriaceae Ongoing monitoring and development of decision support tools/algorithms are needed for identification of high-risk patients.

Keywords: anti-infective agents; bacteremia; bacterial drug resistance; bacterial infections; bacterial pneumonia; carbapenems; intra-abdominal infections; urinary tract infections.

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Figures

FIG 1
FIG 1
Prevalence of carbapenem resistance rates among hospitalized patients with infection due to Enterobacteriaceae, stratified by (A) geographic area (U.S. Centers for Disease Control and Prevention regions, combined cUTI, cIAI, HAP, and BSI) and hospital unit, 2011 to 2014, and (B) infection type. Rates are shown in bold italic type. BSI, bloodstream infection; cIAI, complicated intra-abdominal infection; CRE, carbapenem-resistant Enterobacteriaceae; cUTI, complicated urinary tract infection; HAP, hospital-associated pneumonia; ICU, intensive care unit.
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References

    1. Centers for Disease Control and Prevention. 2013. Antibiotic resistance threats in the United States, 2013. Centers for Disease Control and Prevention, Atlanta, GA.
    1. Gupta K, Hooton TM, Naber KG, Wullt B, Colgan R, Miller LG, Moran GJ, Nicolle LE, Raz R, Schaeffer AJ, Soper DE, Infectious Diseases Society of America, European Society for Microbiology and Infectious Diseases. 2011. International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: a 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases. Clin Infect Dis 52:e103–e120. doi: 10.1093/cid/ciq257. - DOI - PubMed

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