Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Jul 17;56(30):8870-8873.
doi: 10.1002/anie.201703812. Epub 2017 Jun 20.

A Rapid Total Synthesis of Ciprofloxacin Hydrochloride in Continuous Flow

Affiliations

A Rapid Total Synthesis of Ciprofloxacin Hydrochloride in Continuous Flow

Hongkun Lin et al. Angew Chem Int Ed Engl. .

Abstract

Within a total residence time of 9 min, the sodium salt of ciprofloxacin was prepared from simple building blocks via a linear sequence of six chemical reactions in five flow reactors. Sequential offline acidifications and filtrations afforded ciprofloxacin and ciprofloxacin hydrochloride. The overall yield of the eight-step sequence was 60 %. No separation of intermediates was required throughout the synthesis when a single acylation reaction was applied to remove the main byproduct, dimethylamine.

Keywords: aromatic substitution; ciprofloxacin; continuous flow; multicomponent reactions; multistep synthesis.

PubMed Disclaimer

Publication types

LinkOut - more resources