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Randomized Controlled Trial
. 2017 Sep-Oct;10(5):902-909.
doi: 10.1016/j.brs.2017.05.007. Epub 2017 May 19.

Efficacy of transcranial direct current stimulation over primary motor cortex (anode) and contralateral supraorbital area (cathode) on clinical pain severity and mobility performance in persons with knee osteoarthritis: An experimenter- and participant-blinded, randomized, sham-controlled pilot clinical study

Hyochol Ahn  1 , Adam J Woods  2 , Mark E Kunik  3 , Abhishek Bhattacharjee  4 , Zhiguo Chen  4 , Eunyoung Choi  5 , Roger B Fillingim  6
Affiliations
Randomized Controlled Trial

Efficacy of transcranial direct current stimulation over primary motor cortex (anode) and contralateral supraorbital area (cathode) on clinical pain severity and mobility performance in persons with knee osteoarthritis: An experimenter- and participant-blinded, randomized, sham-controlled pilot clinical study

Hyochol Ahn et al. Brain Stimul. 2017 Sep-Oct.

Abstract

Background: Previous studies indicate that transcranial direct current stimulation (tDCS) with anode over motor cortex (M1) and cathode over contralateral supraorbital region (SO) may be effective in reducing pain, but these studies are limited in number and have not focused on older adults with osteoarthritis (OA).

Objective: To evaluate the preliminary efficacy and safety of M1-SO applied tDCS on clinical pain severity and mobility performance in adults with knee OA pain.

Methods: Forty 50- to 70-year-old community-dwelling participants with knee OA were randomly assigned to receive five daily sessions of 2 mA tDCS for 20 min (n = 20) or sham tDCS (n = 20). We measured clinical pain severity via Numeric Rating Scale, Western Ontario and McMaster Universities Osteoarthritis Index, and Short-Form McGill Pain Questionnaire. In addition, we measured mobility performance using the 6-Minute Walk Test and the Short Physical Performance Battery. Moreover, we obtained a sensation/safety questionnaire and measured cognition changes using the PROMIS-Applied Cognition-Abilities-Short Form 8a.

Results: Active tDCS over M1-SO significantly reduced Numeric Rating Scale of pain compared to sham tDCS after completion of the five daily sessions, and remained up to three weeks. No other measures were significantly different from sham. Participants tolerated tDCS over M1-SO well without serious adverse effects or cognition changes.

Conclusion: Although not consistent in all pain measurements, our findings demonstrate promising clinical efficacy for reduction in pain perception for older adults with knee OA.

Trial registration: ClinicalTrials.gov Identifier NCT02512393.

Keywords: Knee osteoarthritis; Mobility performance; Pain; Safety; Transcranial direct current stimulation.

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Conflict of interest statement

Conflict of interest: The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
Participant flow diagram.
See this image and copyright information in PMC

References

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