Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Aug;146(2):405-415.
doi: 10.1016/j.ygyno.2017.05.027. Epub 2017 May 28.

Sentinel lymph node mapping and staging in endometrial cancer: A Society of Gynecologic Oncology literature review with consensus recommendations

Robert W Holloway  1 , Nadeem R Abu-Rustum  2 , Floor J Backes  3 , John F Boggess  4 , Walter H Gotlieb  5 , W Jeffrey Lowery  6 , Emma C Rossi  4 , Edward J Tanner  7 , Rebecca J Wolsky  8
Affiliations
Review

Sentinel lymph node mapping and staging in endometrial cancer: A Society of Gynecologic Oncology literature review with consensus recommendations

Robert W Holloway et al. Gynecol Oncol. 2017 Aug.

Abstract

The emphasis in contemporary medical oncology has been "precision" or "personalized" medicine, terms that imply a strategy to improve efficacy through targeted therapies. Similar attempts at precision are occurring in surgical oncology. Sentinel lymph node (SLN) mapping has recently been introduced into the surgical staging of endometrial cancer with the goal to reduce morbidity associated with comprehensive lymphadenectomy, yet obtain prognostic information from lymph node status. The Society of Gynecologic Oncology's (SGO) Clinical Practice Committee and SLN Working Group reviewed the current literature for preparation of this document. Literature-based recommendations for the inclusion of SLN assessment in the treatment of patients with endometrial cancer are presented. This article examines.

Keywords: Consensus recommendation; Endometrial cancer; Literature review; Pathology & clinical outcomes; Sentinel lymph node mapping; Surgical staging.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest Statement

We declare that there are no direct conflicts of interest associated with this manuscript, except the following relationships:

  1. Dr. Holloway reports personal fees from Intuitive Surgical, Inc., outside the submitted work;

  2. Dr. Boggess reports personal fees from Intuitive Surgical, Inc., outside the submitted work;

  3. Dr. Lowery reports personal fees from AstraZeneca, Inc., outside the submitted work.

Figures

Figure 1.
Figure 1.
Example of left pelvic sentinel lymph node (SLN) following indocyanine green (ICG) cervical injection in endometrial cancer. The lymphatic trunk, SLN, and secondary node are seen. Colored segmented fluorescence (CSF) mode (Novadaq, Ontario) allows the surgeon to see the operative field in four different modes (picture in picture), including a high-definition colored image (left upper quadrant), SPY (black and white with highest precision), green overlay PINPOINT®, and CSF with a color gradient of fluorescent intensity uptake (red highest, blue lowest).
See this image and copyright information in PMC

References

    1. Mikuta JJ. International Federation of Gynecology and Obstetrics staging of endometrial cancer 1988. Cancer. 1993;71:1460–3. - PubMed
    1. Rungruang B, Olawaiye AB. Comprehensive surgical staging for endometrial cancer. Rev Obstet Gynecol. 2012;5:28–34. - PMC - PubMed
    1. Kilgore LC, Partridge EE, Alvarez RD, Austin JM, Shingleton HM, Noojin F 3rd, et al. Adenocarcinoma of the endometrium: Survival comparisons of patients with and without pelvic node sampling. Gynecol Oncol. 1995;56:29–33. - PubMed
    1. Trimble EL, Kosary C, Park RC. Lymph node sampling and survival in endometrial cancer. Gynecol Oncol. 1998;71:340–3. - PubMed
    1. Chan JK, Cheung MK, Huh WK, Osann K, Husain A, Teng NN, et al. Therapeutic role of lymph node resection in endometrioid corpus cancer: A study of 12,333 patients. Cancer. 2006;107:1823–30. - PubMed

Publication types

MeSH terms

LinkOut - more resources