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Comment
. 2017 May 31;9(392):eaan4297.
doi: 10.1126/scitranslmed.aan4297.

A new therapeutic target for myelofibrosis is cause for Gli

Brian A Jonas  1
Affiliations
Comment

A new therapeutic target for myelofibrosis is cause for Gli

Brian A Jonas. Sci Transl Med. .

Abstract

Myeloproliferative neoplasm cells recruit Gli1 positive mesenchymal stromal cells to transdifferentiate into fibrosis-causing myofibroblasts, a process that can be inhibited by a Gli inhibitor.

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