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Editorial
. 2017 Jul;28(7):1953-1955.
doi: 10.1681/ASN.2017040398. Epub 2017 May 31.

ILC2: There's a New Cell in Town

Yuan Min Wang  1 , Mahnoor Bakhtiar  1 , Stephen I Alexander  2
Affiliations
Editorial

ILC2: There's a New Cell in Town

Yuan Min Wang et al. J Am Soc Nephrol. 2017 Jul.
No abstract available

Keywords: IL-33; ILC2; chronic kidney disease.

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Figures

Figure 1.
Figure 1.
IL-33 treatment induced the expansion of the IL-33 receptor (IL-33R)-positive ILC2s and ameliorated CKD in the AN model. Human ILC2s express the surface markers T1/ST2 (IL-33R), CD80/86, MHCII, CD25, CD127, and CRTH2 and have the transcription factors GATA3 and RORα. IL-33–mediated expansion of ILC2s leads to secretion of IL-5 and IL-13, downregulation of IFN-γ, TNF-α, and GM-CSF, and protection from injury in AN.
See this image and copyright information in PMC

Comment on

References

    1. Artis D, Spits H: The biology of innate lymphoid cells. Nature 517: 293–301, 2015 - PubMed
    1. Eberl G, Di Santo JP, Vivier E: The brave new world of innate lymphoid cells. Nat Immunol 16: 1–5, 2015 - PubMed
    1. Riedel JH, Becker M, Kopp K, Düster M, Brix SR, Meyer-Schwesinger C, Kluth LA, Gnirck AC, Attar M, Krohn S, Fehse B, Stahl RA, Panzer U, Turner JE: IL-33-mediated expansion of type 2 innate lymphoid cells protects from progressive glomerulosclerosis. J Am Soc Nephrol 28: 2068–2080, 2017 - PMC - PubMed
    1. Huang Y, Guo L, Qiu J, Chen X, Hu-Li J, Siebenlist U, Williamson PR, Urban JF Jr., Paul WE: IL-25-responsive, lineage-negative KLRG1(hi) cells are multipotential ‘inflammatory’ type 2 innate lymphoid cells. Nat Immunol 16: 161–169, 2015 - PMC - PubMed
    1. von Moltke J, O’Leary CE, Barrett NA, Kanaoka Y, Austen KF, Locksley RM: Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s. J Exp Med 214: 27–37, 2017 - PMC - PubMed