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Comment
. 2017 Sep-Oct;19(5):512-514.
doi: 10.4103/aja.aja_14_17.

Testosterone treatment in older men: glass half empty or half full?

Brendan J Nolan  1 , Mathis Grossmann  1   2
Affiliations
Comment

Testosterone treatment in older men: glass half empty or half full?

Brendan J Nolan et al. Asian J Androl. 2017 Sep-Oct.

Abstract

In a series of randomized controlled trials published in JAMA and JAMA Intern Med, US researchers have examined the effect of testosterone treatment in older men with testosterone levels <275 ng dl−1 on coronary artery plaque volume, cognitive function, anemia, and volumetric bone density. While the trials have shown positive results with respect to improvement in anemia and bone density, longer-term studies are required to delineate the long-term risks and benefits in this population.

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Comment on

  • Testosterone Treatment and Coronary Artery Plaque Volume in Older Men With Low Testosterone.
    Budoff MJ, Ellenberg SS, Lewis CE, Mohler ER 3rd, Wenger NK, Bhasin S, Barrett-Connor E, Swerdloff RS, Stephens-Shields A, Cauley JA, Crandall JP, Cunningham GR, Ensrud KE, Gill TM, Matsumoto AM, Molitch ME, Nakanishi R, Nezarat N, Matsumoto S, Hou X, Basaria S, Diem SJ, Wang C, Cifelli D, Snyder PJ. Budoff MJ, et al. JAMA. 2017 Feb 21;317(7):708-716. doi: 10.1001/jama.2016.21043. JAMA. 2017. PMID: 28241355 Free PMC article. Clinical Trial.
  • Testosterone Treatment and Cognitive Function in Older Men With Low Testosterone and Age-Associated Memory Impairment.
    Resnick SM, Matsumoto AM, Stephens-Shields AJ, Ellenberg SS, Gill TM, Shumaker SA, Pleasants DD, Barrett-Connor E, Bhasin S, Cauley JA, Cella D, Crandall JP, Cunningham GR, Ensrud KE, Farrar JT, Lewis CE, Molitch ME, Pahor M, Swerdloff RS, Cifelli D, Anton S, Basaria S, Diem SJ, Wang C, Hou X, Snyder PJ. Resnick SM, et al. JAMA. 2017 Feb 21;317(7):717-727. doi: 10.1001/jama.2016.21044. JAMA. 2017. PMID: 28241356 Free PMC article. Clinical Trial.

References

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    1. Resnick SM, Matsumoto AM, Stephens-Shields AJ, Ellenberg SS, Gill TM, et al. Testosterone treatment and cognitive function in older men with low testosterone and age-associated memory impairment. JAMA. 2017;317:717–27. - PMC - PubMed
    1. Roy CN, Snyder PJ, Stephens-Shields AJ, Artz AS, Bhasin S, et al. Association of testosterone levels with anemia in older men: a controlled clinical trial. JAMA Intern Med. 2017;177:480–90. - PMC - PubMed
    1. Snyder PJ, Kopperdahl DL, Stephens-Shields AJ, Ellenberg SS, Cauley JA, et al. Effect of testosterone treatment on volumetric bone density and strength in older men with low testosterone: a controlled clinical trial. JAMA Intern Med. 2017;177:471–9. - PMC - PubMed
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