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Review
. 2017 Aug;44(Suppl 1):84-96.
doi: 10.1007/s00259-017-3734-0. Epub 2017 May 31.

Therapy assessment of bone metastatic disease in the era of 223radium

Elba Etchebehere  1 , Ana Emilia Brito  1 , Alireza Rezaee  2 , Werner Langsteger  2 , Mohsen Beheshti  3   4
Affiliations
Review

Therapy assessment of bone metastatic disease in the era of 223radium

Elba Etchebehere et al. Eur J Nucl Med Mol Imaging. 2017 Aug.

Abstract

Purpose: Defining an optimal imaging modality for assessment of therapy and the best time of evaluation are pivotal for ideal patient's management.

Methods: 223Ra (Xofigo®, formerly Alpharadin) has been approved by the FDA and European Medicines Agency for treatment of metastatic castration-resistant prostate cancer with painful osseous involvement.

Results: PET/CT imaging using various radiotracers such as 18F-FDG, 18F-FCH, 68Ga-PSMA and 18F-NaF have been investigated to mitigate the limitations of conventional imaging modalities. Diagnostic radiotracers that have properties similar to a therapeutic radiotracer will precisely assess of the possibility and efficacy of a treatment; this is the theranostic concept. An example of a diagnostic test employed for selecting targeted therapy is the combined use of 18F-fluoride PET/CT for evaluation of possible therapy with 223Ra.

Conclusion: This review examines the most recent publications related to this topic.

Keywords: 223Ra; Bone metastasis; Prostate cancer; Therapy monitoring.

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