Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1985 Jan;131(1):169-70.
doi: 10.1164/arrd.1985.131.1.169.

Stimulation of lung lysyl oxidase activity in hamsters with elastase-induced emphysema

M Osman, R R Kaldany, J O Cantor, G M Turino, I Mandl

Stimulation of lung lysyl oxidase activity in hamsters with elastase-induced emphysema

M Osman et al. Am Rev Respir Dis. 1985 Jan.

Abstract

Lysyl oxidase activity was measured in lung extracts of hamsters with elastase-induced emphysema 8 days after administration of the enzyme and again after 2, 3, and 4 wk. Levels of activity rose rapidly to 7 times the base values determined in the lungs of saline-injected control animals. In parallel with the increase in lysyl oxidase activity, the rate of 14C-lysine incorporation into desmosine and isodesmosine was at its maximum 1 wk after elastase administration, reflecting the lysyl-oxidase-mediated cross-link formation, which is the final step in the resynthesis of the pulmonary elastin destroyed by the elastolytic insult.

PubMed Disclaimer

Publication types

LinkOut - more resources