Non-survivor septic patients have persistently higher serum sCD40L levels than survivors

doi:10.1016/j.jcrc.2017.05.021

Observational Study

. 2017 Oct:41:177-182.

doi: 10.1016/j.jcrc.2017.05.021. Epub 2017 May 24.

Non-survivor septic patients have persistently higher serum sCD40L levels than survivors

Leonardo Lorente¹, María M Martín², Antonia Pérez-Cejas³, José Ferreres⁴, Jordi Solé-Violán⁵, Lorenzo Labarta⁶, César Díaz⁷, Alejandro Jiménez⁸

Affiliations

¹ Intensive Care Unit, Hospital Universitario de Canarias, Ofra, s/n, La Laguna 38320, Tenerife, Spain. Electronic address: lorentemartin@msn.com.
² Intensive Care Unit, Hospital Universitario Nuestra Señora Candelaria, Crta Rosario s/n, Santa Cruz Tenerife 38010, Spain. Electronic address: mar.martinvelasco@gmail.com.
³ Laboratory Deparment, Hospital Universitario de Canarias, Ofra, s/n, La Laguna 38320, Tenerife, Spain. Electronic address: aperezcejas@gmail.com.
⁴ Intensive Care Unit, Hospital Clínico Universitario de Valencia, Avda. Blasco Ibáñez no17-19, Valencia 46004, Spain. Electronic address: ferreresj@gmail.com.
⁵ Intensive Care Unit. Hospital Universitario Dr. Negrín, Barranco de la Ballena s/n, Las Palmas de Gran Canaria 35010, Spain. Electronic address: jsolvio@gobiernodecanarias.org.
⁶ Intensive Care Unit, Hospital San Jorge de Huesca, Avenida Martínez de Velasco no36, Huesca 22004, Spain. Electronic address: llabarta@salud.aragon.es.
⁷ Intensive Care Unit, Hospital Insular, Plaza Dr. Pasteur s/n, Las Palmas de Gran Canaria 35016, Spain. Electronic address: incaicos@yahoo.es.
⁸ Research Unit, Hospital Universitario de Canarias, Ofra, s/n, La Laguna 38320, Tenerife, Spain. Electronic address: ajimenezsosa@gmail.com.

PMID: 28570959
DOI: 10.1016/j.jcrc.2017.05.021

Observational Study

Non-survivor septic patients have persistently higher serum sCD40L levels than survivors

Leonardo Lorente et al. J Crit Care. 2017 Oct.

. 2017 Oct:41:177-182.

doi: 10.1016/j.jcrc.2017.05.021. Epub 2017 May 24.

Authors

Leonardo Lorente¹, María M Martín², Antonia Pérez-Cejas³, José Ferreres⁴, Jordi Solé-Violán⁵, Lorenzo Labarta⁶, César Díaz⁷, Alejandro Jiménez⁸

Affiliations

¹ Intensive Care Unit, Hospital Universitario de Canarias, Ofra, s/n, La Laguna 38320, Tenerife, Spain. Electronic address: lorentemartin@msn.com.
² Intensive Care Unit, Hospital Universitario Nuestra Señora Candelaria, Crta Rosario s/n, Santa Cruz Tenerife 38010, Spain. Electronic address: mar.martinvelasco@gmail.com.
³ Laboratory Deparment, Hospital Universitario de Canarias, Ofra, s/n, La Laguna 38320, Tenerife, Spain. Electronic address: aperezcejas@gmail.com.
⁴ Intensive Care Unit, Hospital Clínico Universitario de Valencia, Avda. Blasco Ibáñez no17-19, Valencia 46004, Spain. Electronic address: ferreresj@gmail.com.
⁵ Intensive Care Unit. Hospital Universitario Dr. Negrín, Barranco de la Ballena s/n, Las Palmas de Gran Canaria 35010, Spain. Electronic address: jsolvio@gobiernodecanarias.org.
⁶ Intensive Care Unit, Hospital San Jorge de Huesca, Avenida Martínez de Velasco no36, Huesca 22004, Spain. Electronic address: llabarta@salud.aragon.es.
⁷ Intensive Care Unit, Hospital Insular, Plaza Dr. Pasteur s/n, Las Palmas de Gran Canaria 35016, Spain. Electronic address: incaicos@yahoo.es.
⁸ Research Unit, Hospital Universitario de Canarias, Ofra, s/n, La Laguna 38320, Tenerife, Spain. Electronic address: ajimenezsosa@gmail.com.

PMID: 28570959
DOI: 10.1016/j.jcrc.2017.05.021

Abstract

Introduction: Soluble CD40 ligand (sCD40L) is a protein with proinflammatory and prothrombotic effects. Previously we found higher circulating sCD40L levels in non-survivor than in survivor patients at sepsis diagnosis. Now some questions arise such as how are serum sCD40L levels during the first week of severe sepsis?, is there an association between serum sCD40L levels during the first week and mortality?, and serum sCD40L levels during the first week could be used as sepsis mortality biomarker?. This study was developed to answer these asks.

Methods: Study from 6 Spanish Intensive Care Units with 291 severe septic patients. There were determined serum levels of sCD40L and tumor necrosis factor (TNF)-alpha during the first week. The end-point study was 30-day mortality.

Results: We found that serum sCD40L at days 1, 4, and 8 could predict mortality at 30days, and are associated with mortality.

Conclusions: The novel findings of our study were that there were higher serum sCD40L levels persistently during the first week in non-survivor than in survivor patients, that there is an association between serum sCD40L levels during the first week and sepsis mortality, and that serum sCD40L levels during the first week could be used as sepsis mortality biomarker.

Keywords: Mortality; Sepsis; sCD40L.

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Non-survivor septic patients have persistently higher serum sCD40L levels than survivors

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Non-survivor septic patients have persistently higher serum sCD40L levels than survivors

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