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Review
. 2017 Jun;17(3):274-277.
doi: 10.7861/clinmedicine.17-3-274.

Thyrotoxicosis - investigation and management

Jackie Gilbert  1
Affiliations
Review

Thyrotoxicosis - investigation and management

Jackie Gilbert. Clin Med (Lond). 2017 Jun.

Abstract

Graves' disease (GD) and toxic nodular (TN) goitre account for most cases of thyrotoxicosis associated with hyperthyroidism. Hyperthyroidism is confirmed with measurement of a suppressed serum thyrotropin concentration (TSH) and elevated free thyroid hormones. The three therapeutic options are antithyroid drugs, radioactive iodine and surgery. Thionamides achieve long-term remission in 35% of cases. Many centres administer fixed doses of iodine-131; larger doses result in improved rates of cure at the cost of hypothyroidism. Surgery is usually considered for patients who have a large goitre, compressive symptoms or significant ophthalmopathy.

Keywords: Grave’s disease; radioiodine; thionamides; thyroidectomy; thyrotoxicosis.

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