Multi-morbidities of allergic rhinitis in adults: European Academy of Allergy and Clinical Immunology Task Force Report

C Cingi¹, P Gevaert², R Mösges³, C Rondon⁴, V Hox⁵, M Rudenko⁶, N B Muluk⁷, G Scadding⁸, F Manole⁹, C Hupin¹⁰, W J Fokkens¹¹, C Akdis¹², C Bachert², P Demoly¹³, J Mullol¹⁴, A Muraro¹⁵, N Papadopoulos¹⁶, R Pawankar¹⁷, P Rombaux¹⁸, E Toskala¹⁹, L Kalogjera²⁰, E Prokopakis²¹, P W Hellings⁵, J Bousquet¹³

Affiliations

¹ Department of Otorhinolaryngology, Eskisehir Osmangazi University School of Medicine, Eskisehir, Turkey.
² Upper Airway Research Laboratory, Ghent University Hospital, Ghent, Belgium.
³ Institute of Medical Statistics, Informatics, and Epidemiology, Medical Faculty, University of Köln, Cologne, Germany.
⁴ Allergy Unit, IBIMA, Regional University Hospital of Malaga, UMA, Malaga, Spain.
⁵ Clinical division of Otorhinolaryngology, Head and Neck Surgery, University Hospitals Leuven, Louvain, Belgium.
⁶ London Allergy and Immunology Centre, London, UK.
⁷ ENT Department, Faculty of Medicine, Kirikkale University, Kirikkale, Turkey.
⁸ Royal National Throat, Nose and Ear Hospital, London, UK.
⁹ Faculty of Medicine, ENT Department, University of Oradea, Oradea, Romania.
¹⁰ Institut de Recherche Expérimentale et Clinique (IREC), Pole de Pneumologie, ORL & Dermatologie, Université catholique de Louvain, Louvain-la-Neuve, Belgium.
¹¹ Department of Otorhinolaryngology, Head and Neck Surgery, Academic Medical Centre (AMC), Amsterdam, The Netherlands.
¹² Christine Kuhne-Center for Allergy Research and Education, Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland.
¹³ Hôpital Arnaud de Villeneuve, University Hospital of Montpellier, Montpellier, France.
¹⁴ Unitat de Rinologia i Clinica de l'Olfacte, Servei d'Otorinolaringologia, Hospital Clínic, Barcelona, Catalonia Spain.
¹⁵ The Referral Centre for Food Allergy Diagnosis and Treatment Veneto Region, Department of Mother and Child Health, University of Padua, Padua, Italy.
¹⁶ Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece.
¹⁷ Nippon Medical School, Tokyo, Japan.
¹⁸ Service d'ORL, Cliniques Universitaires St-Luc, Brussels, Belgium.
¹⁹ Department of Otorhinolaryngology-Head and Neck Surgery, Temple University, Philadelphia, PA USA.
²⁰ Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Sestre milosrdnice, Zagreb, Croatia.
²¹ Department of Otorhinolaryngology, University Hospital of Crete, Crete, Greece.

PMID: 28572918
PMCID: PMC5452333
DOI: 10.1186/s13601-017-0153-z

Review

Multi-morbidities of allergic rhinitis in adults: European Academy of Allergy and Clinical Immunology Task Force Report

C Cingi et al. Clin Transl Allergy. 2017.

. 2017 Jun 1:7:17.

doi: 10.1186/s13601-017-0153-z. eCollection 2017.

Authors

Affiliations

¹ Department of Otorhinolaryngology, Eskisehir Osmangazi University School of Medicine, Eskisehir, Turkey.
² Upper Airway Research Laboratory, Ghent University Hospital, Ghent, Belgium.
³ Institute of Medical Statistics, Informatics, and Epidemiology, Medical Faculty, University of Köln, Cologne, Germany.
⁴ Allergy Unit, IBIMA, Regional University Hospital of Malaga, UMA, Malaga, Spain.
⁵ Clinical division of Otorhinolaryngology, Head and Neck Surgery, University Hospitals Leuven, Louvain, Belgium.
⁶ London Allergy and Immunology Centre, London, UK.
⁷ ENT Department, Faculty of Medicine, Kirikkale University, Kirikkale, Turkey.
⁸ Royal National Throat, Nose and Ear Hospital, London, UK.
⁹ Faculty of Medicine, ENT Department, University of Oradea, Oradea, Romania.
¹⁰ Institut de Recherche Expérimentale et Clinique (IREC), Pole de Pneumologie, ORL & Dermatologie, Université catholique de Louvain, Louvain-la-Neuve, Belgium.
¹¹ Department of Otorhinolaryngology, Head and Neck Surgery, Academic Medical Centre (AMC), Amsterdam, The Netherlands.
¹² Christine Kuhne-Center for Allergy Research and Education, Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland.
¹³ Hôpital Arnaud de Villeneuve, University Hospital of Montpellier, Montpellier, France.
¹⁴ Unitat de Rinologia i Clinica de l'Olfacte, Servei d'Otorinolaringologia, Hospital Clínic, Barcelona, Catalonia Spain.
¹⁵ The Referral Centre for Food Allergy Diagnosis and Treatment Veneto Region, Department of Mother and Child Health, University of Padua, Padua, Italy.
¹⁶ Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece.
¹⁷ Nippon Medical School, Tokyo, Japan.
¹⁸ Service d'ORL, Cliniques Universitaires St-Luc, Brussels, Belgium.
¹⁹ Department of Otorhinolaryngology-Head and Neck Surgery, Temple University, Philadelphia, PA USA.
²⁰ Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Sestre milosrdnice, Zagreb, Croatia.
²¹ Department of Otorhinolaryngology, University Hospital of Crete, Crete, Greece.

PMID: 28572918
PMCID: PMC5452333
DOI: 10.1186/s13601-017-0153-z

Abstract

This report has been prepared by the European Academy of Allergy and Clinical Immunology Task Force on Allergic Rhinitis (AR) comorbidities. The aim of this multidisciplinary European consensus document is to highlight the role of multimorbidities in the definition, classification, mechanisms, recommendations for diagnosis and treatment of AR, and to define the needs in this neglected area by a literature review. AR is a systemic allergic disease and is generally associated with numerous multi-morbid disorders, including asthma, eczema, food allergies, eosinophilic oesophagitis (EoE), conjunctivitis, chronic middle ear effusions, rhinosinusitis, adenoid hypertrophy, olfaction disorders, obstructive sleep apnea, disordered sleep and consequent behavioural and educational effects. This report provides up-to-date usable information to: (1) improve the knowledge and skills of allergists, so as to ultimately improve the overall quality of patient care; (2) to increase interest in this area; and (3) to present a unique contribution to the field of upper inflammatory disease.

Keywords: Adenoid hypertrophy; Allergic rhinitis (AR); Asthma; Chronic middle ear effusions; Comorbidities; Conjunctivitis; Disordered sleep; Eczema; Eosinophilic oesophagitis (EoE); Food allergies; Obstructive sleep apnea; Olfaction disorders; Rhinitis; Rhinosinusitis.

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Figures

**Fig. 1**
Treatment for AR (taken from ARIA 2012) [104]. In addition to the pathways presented in the figure allergen and irritant avoidance may be appropriate; for conjunctivitis, add an oral H1-blocker, intraocular H1-blocker or intraocular cromone (or saline); consider specific immunotherapy when pharmacotherapy fails or is unacceptable to the patient

See this image and copyright information in PMC

References

1. Sih T, Mion O. Allergic rhinitis in the child and associated comorbidities. Pediatr Allergy Immunol. 2010;21:e107–e113. doi: 10.1111/j.1399-3038.2009.00933.x. - DOI - PubMed
1. Scadding GK, Bousquet J. Introduction: allergic rhinitis. Allergy. 2007;62(Suppl 85):3–5. doi: 10.1111/j.1398-9995.2007.01546.x. - DOI - PubMed
1. Roberts G, Xatzipsalti M, Borrego LM, Custovic A, Halken S, Hellings PW, et al. Paediatric rhinitis: position paper of the European academy of allergy and clinical immunology. Allergy. 2013;68:1102–1116. - PubMed
1. Comorbidity [Internet]. Wikipedia, the free encyclopedia. http://en.wikipedia.org/wiki/Comorbidity. Accessed 2 Dec 2013.
1. Lack G. Pediatric allergic rhinitis and comorbid disorders. J Allergy Clin Immunol. 2001;108(Suppl 1):S9–S15. doi: 10.1067/mai.2001.115562. - DOI - PubMed

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Multi-morbidities of allergic rhinitis in adults: European Academy of Allergy and Clinical Immunology Task Force Report

Affiliations

Multi-morbidities of allergic rhinitis in adults: European Academy of Allergy and Clinical Immunology Task Force Report

Authors

Affiliations

Abstract

Figures

References

Publication types

LinkOut - more resources

Full Text Sources

Other Literature Sources

Research Materials