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Comment
. 2017 Aug;24(8):1311-1313.
doi: 10.1038/cdd.2017.83. Epub 2017 Jun 2.

Exploiting tumour addiction with a serine and glycine-free diet

Ivano Amelio  1 , Gerry Melino  1   2 , Christian Frezza  3
Affiliations
Comment

Exploiting tumour addiction with a serine and glycine-free diet

Ivano Amelio et al. Cell Death Differ. 2017 Aug.
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The serine synthesis pathway (SSP) diverges from glycolysis utilising the intermediate 3P-glycerate, which is converted by PHGDH, PSAT-1, and PSPH into serine and then glycine. Removal of exogenous serine and glycine causes activation of SSP, however Vousden’s study demonstrates that tumours, such as Eμ-Myc- and ApcMin/+-driven lymphomas and intestinal lesions can be susceptible to serine and glycine (SG) deprivation. Concurrent SG dietary restriction and biguanide administration might improve anti-tumour effects when associated with a reduction in antioxidant defence. On contrary, Kras-driven pancreatic tumours appear resistant to SG-free diet as observed from the ability of Kras to promote expression of PHGDH, PSAT-1, and PSPH and thus boost activity of SSP. This figure is re-adapted from Amelio and Melino
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References

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