doi: 10.1073/pnas.82.2.617.
Complete coding sequence of rat tyrosine hydroxylase mRNA
- PMID: 2857492
- PMCID: PMC397092
- DOI: 10.1073/pnas.82.2.617
Item in Clipboard
Complete coding sequence of rat tyrosine hydroxylase mRNA
Proc Natl Acad Sci U S A.
1985 Jan.
Abstract
Several clones specific for tyrosine hydroxylase [tyrosine 3-monooxygenase, L-tyrosine, tetrahydropteridine:oxygen oxidoreductase (3-hydroxylating), EC 1.14.16.2] have been identified from a rat PC12 library by using the previously characterized clone pTH-1. The most complete of these, pTH-51, is 1758 base pairs long and covers most of the length of the mRNA, including the entire coding and 3' untranslated region. The polypeptide has an estimated molecular weight of 55,903 and some of its characteristic features are discussed.
Similar articles
-
Isolation and sequence of a cDNA clone which contains the complete coding region of rat phenylalanine hydroxylase. Structural homology with tyrosine hydroxylase, glucocorticoid regulation, and use of alternate polyadenylation sites.J Biol Chem. 1986 Mar 25;261(9):4148-53. J Biol Chem. 1986. PMID: 2869038
-
Identification of cDNA clones coding for rat tyrosine hydroxylase antigen.Proc Natl Acad Sci U S A. 1982 Jun;79(12):3881-5. doi: 10.1073/pnas.79.12.3881. Proc Natl Acad Sci U S A. 1982. PMID: 6179090 Free PMC article.
-
Complete nucleotide and deduced amino acid sequence of bovine phenylethanolamine N-methyltransferase: partial amino acid homology with rat tyrosine hydroxylase.Proc Natl Acad Sci U S A. 1986 Aug;83(15):5454-8. doi: 10.1073/pnas.83.15.5454. Proc Natl Acad Sci U S A. 1986. PMID: 2874553 Free PMC article.
-
Isolation and nucleotide sequence of a cDNA clone encoding bovine adrenal tyrosine hydroxylase: comparative analysis of tyrosine hydroxylase gene products.J Neurosci Res. 1988 Apr;19(4):440-9. doi: 10.1002/jnr.490190408. J Neurosci Res. 1988. PMID: 2898537
-
Isolation and characterization of the human tyrosine hydroxylase gene: identification of 5' alternative splice sites responsible for multiple mRNAs.Biochemistry. 1987 Nov 3;26(22):6910-4. doi: 10.1021/bi00396a007. Biochemistry. 1987. PMID: 2892528
Cited by
-
Human Bacterial Artificial Chromosome (BAC) Transgenesis Fully Rescues Noradrenergic Function in Dopamine β-Hydroxylase Knockout Mice.PLoS One. 2016 May 5;11(5):e0154864. doi: 10.1371/journal.pone.0154864. eCollection 2016. PLoS One. 2016. PMID: 27148966 Free PMC article.
-
Modulation of tyrosine hydroxylase gene expression in the central nervous system visualized by in situ hybridization.Proc Natl Acad Sci U S A. 1987 Mar;84(6):1699-703. doi: 10.1073/pnas.84.6.1699. Proc Natl Acad Sci U S A. 1987. PMID: 2882513 Free PMC article.
-
EZH2 Is Essential for Fate Determination in the Mammalian Isthmic Area.Front Mol Neurosci. 2019 Apr 9;12:76. doi: 10.3389/fnmol.2019.00076. eCollection 2019. Front Mol Neurosci. 2019. PMID: 31024250 Free PMC article.
-
A peripherally administered, centrally acting angiotensin II AT2 antagonist selectively increases brain AT1 receptors and decreases brain tyrosine hydroxylase transcription, pituitary vasopressin and ACTH.Brain Res. 2009 Jan 23;1250:130-40. doi: 10.1016/j.brainres.2008.11.006. Epub 2008 Nov 12. Brain Res. 2009. PMID: 19038235 Free PMC article.
-
Striatonigral GABA, dynorphin, substance P and neurokinin A modulation of nigrostriatal dopamine release: evidence for direct regulatory mechanisms.Exp Brain Res. 1990;82(2):293-303. doi: 10.1007/BF00231249. Exp Brain Res. 1990. PMID: 1704847
References
Publication types
MeSH terms
Substances
Associated data
- Actions
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
