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Comment
. 2017 Jun 1;169(6):981-982.
doi: 10.1016/j.cell.2017.05.027.

Curbing Tregs' (Lack of) Enthusiasm

Taha Merghoub  1 , Jedd D Wolchok  2
Affiliations
Free article
Comment

Curbing Tregs' (Lack of) Enthusiasm

Taha Merghoub et al. Cell. .
Free article

Abstract

In this issue, Overacre-Delgoffe et al. show that interferon gamma production by a subset of regulatory T cells in the tumor microenvironment triggers Treg instability locally and restores anti-tumor immunity.

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  • Interferon-γ Drives Treg Fragility to Promote Anti-tumor Immunity.
    Overacre-Delgoffe AE, Chikina M, Dadey RE, Yano H, Brunazzi EA, Shayan G, Horne W, Moskovitz JM, Kolls JK, Sander C, Shuai Y, Normolle DP, Kirkwood JM, Ferris RL, Delgoffe GM, Bruno TC, Workman CJ, Vignali DAA. Overacre-Delgoffe AE, et al. Cell. 2017 Jun 1;169(6):1130-1141.e11. doi: 10.1016/j.cell.2017.05.005. Epub 2017 May 25. Cell. 2017. PMID: 28552348 Free PMC article.

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