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. 2017 Jun 1;20(6):743-745.
doi: 10.1016/j.stem.2017.05.018.

The Dynamic Identity of Intestinal Cancer Stem Cells

Piero Dalerba  1
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The Dynamic Identity of Intestinal Cancer Stem Cells

Piero Dalerba. Cell Stem Cell. .
Free article

Abstract

Elimination of self-renewing cancer stem cells (CSCs) is necessary to permanently eradicate malignant tissues. In a recent article in Nature, de Sousa e Melo et al. (2017) reveal that intestinal tumors can contain dynamic pools of functionally distinct CSC populations, which seem to interconvert depending on the host tissue microenvironment.

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