Novel Opportunities to Use Radiation Therapy with Immune Checkpoint Inhibitors for Melanoma Management

Abstract

Immunotherapy has revolutionized the systemic management of numerous malignancies. Nowhere has the proven benefit of these agents in clinical practice been more evident than in the management of advanced melanoma. Numerous preclinical studies have revealed the potential benefit of immune-priming radiotherapy in stimulating tumor-specific immune responses. This signal for immune activation may lead to clinically relevant synergy with immune checkpoint inhibitors against malignant cells. In this review, the authors summarize the current data outlining the role radiation therapy may play in the management of advanced melanoma alongside immune checkpoint inhibitors.

Keywords: Abscopal effect; Bystander effect; Immune checkpoint inhibitors; Radiation therapy.