. 2017 Sep;27(9):420-427.

doi: 10.1016/j.je.2016.08.017. Epub 2017 May 30.

Interactions between inflammatory gene polymorphisms and HTLV-I infection for total death, incidence of cancer, and atherosclerosis-related diseases among the Japanese population

Tara Sefanya Kairupan¹, Rie Ibusuki², Motahare Kheradmand³, Yasuko Sagara⁴, Eva Mariane Mantjoro⁵, Yora Nindita⁶, Hideshi Niimura⁷, Kazuyo Kuwabara⁸, Shin Ogawa⁹, Noriko Tsumematsu-Nakahata¹⁰, Yasuhito Nerome¹¹, Tetsuhiro Owaki¹¹, Toshifumi Matsushita¹², Shigeho Maenohara¹³, Kazunari Yamaguchi¹⁴, Toshiro Takezaki¹⁵

Affiliations

¹ Department of International Islands and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan; Faculty of Medicine, Sam Ratulangi University, Manado, Indonesia.
² Department of International Islands and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
³ Mazandaran University of Medical Sciences, Sari, Iran.
⁴ Japanese Red Cross Kyushu Block Blood Center, Fukuoka, Japan.
⁵ Faculty of Public Health, Sam Ratulangi University, Manado, Indonesia.
⁶ Department of International Islands and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan; Faculty of Medicine, Diponegoro University, Semarang, Indonesia.
⁷ Yonemori Hospital, Kagoshima, Japan.
⁸ Department of Preventive Medicine and Public Health, Keio University School of Medicine, Tokyo, Japan.
⁹ National Health Insurance Yamato Clinic, Yamato, Japan.
¹⁰ Department of Community Medicine Management, Faculty of Medicine, Shimane University, Izumo, Japan.
¹¹ Education Center for Doctors in Remote Islands and Rural Areas, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
¹² Japan Health Club, Kagoshima, Japan.
¹³ JA Kagoshima Kouseiren Medical Health Care Center, Kagoshima, Japan.
¹⁴ National Institute of Infectious Diseases, Tokyo, Japan.
¹⁵ Department of International Islands and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. Electronic address: takezaki@m.kufm.kagoshima-u.ac.jp.

PMID: 28576445
PMCID: PMC5565753
DOI: 10.1016/j.je.2016.08.017

Interactions between inflammatory gene polymorphisms and HTLV-I infection for total death, incidence of cancer, and atherosclerosis-related diseases among the Japanese population

Tara Sefanya Kairupan et al. J Epidemiol. 2017 Sep.

. 2017 Sep;27(9):420-427.

doi: 10.1016/j.je.2016.08.017. Epub 2017 May 30.

Authors

Affiliations

¹ Department of International Islands and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan; Faculty of Medicine, Sam Ratulangi University, Manado, Indonesia.
² Department of International Islands and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
³ Mazandaran University of Medical Sciences, Sari, Iran.
⁴ Japanese Red Cross Kyushu Block Blood Center, Fukuoka, Japan.
⁵ Faculty of Public Health, Sam Ratulangi University, Manado, Indonesia.
⁶ Department of International Islands and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan; Faculty of Medicine, Diponegoro University, Semarang, Indonesia.
⁷ Yonemori Hospital, Kagoshima, Japan.
⁸ Department of Preventive Medicine and Public Health, Keio University School of Medicine, Tokyo, Japan.
⁹ National Health Insurance Yamato Clinic, Yamato, Japan.
¹⁰ Department of Community Medicine Management, Faculty of Medicine, Shimane University, Izumo, Japan.
¹¹ Education Center for Doctors in Remote Islands and Rural Areas, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
¹² Japan Health Club, Kagoshima, Japan.
¹³ JA Kagoshima Kouseiren Medical Health Care Center, Kagoshima, Japan.
¹⁴ National Institute of Infectious Diseases, Tokyo, Japan.
¹⁵ Department of International Islands and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. Electronic address: takezaki@m.kufm.kagoshima-u.ac.jp.

PMID: 28576445
PMCID: PMC5565753
DOI: 10.1016/j.je.2016.08.017

Abstract

Background: An increased risk of total death owing to human T-lymphotropic virus type-I (HTLV-I) infection has been reported. However, its etiology and protective factors are unclear. Various studies reported fluctuations in immune-inflammatory status among HTLV-I carriers. We conducted a matched cohort study among the general population in an HTLV-I-endemic region of Japan to investigate the interaction between inflammatory gene polymorphisms and HTLV-I infection for total death, incidence of cancer, and atherosclerosis-related diseases.

Method: We selected 2180 sub-cohort subjects aged 35-69 years from the cohort population, after matching for age, sex, and region with HTLV-I seropositives. They were followed up for a maximum of 10 years. Inflammatory gene polymorphisms were selected from TNF-α, IL-10, and NF-κB1. A Cox proportional hazard model was used to estimate the hazard ratio (HR) and the interaction between gene polymorphisms and HTLV-I for risk of total death and incidence of cancer and atherosclerosis-related diseases.

Results: HTLV-I seropositivity rate was 6.4% in the cohort population. The interaction between TNF-α 1031T/C and HTLV-I for atherosclerosis-related disease incidence was statistically significant (p = 0.020). No significant interaction was observed between IL-10 819T/C or NF-κB1 94ATTG ins/del and HTLV-I. An increased HR for total death was observed in the Amami island region, after adjustment of various factors with gene polymorphisms (HR 3.03; 95% confidence interval, 1.18-7.77).

Conclusion: The present study found the interaction between TNF-α 1031T/C and HTLV-I to be a risk factor for atherosclerosis-related disease. Further follow-up is warranted to investigate protective factors against developing diseases among susceptible HTLV-I carriers.

Keywords: Gene polymorphism; HTLV-I; Inflammation; Interaction.

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Figures

**Fig. 1**
Flow-chart of the selection process of the sub-cohort subjects. ^aIncluded 5 death cases. ^bIncluded 1 death case.

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Interactions between inflammatory gene polymorphisms and HTLV-I infection for total death, incidence of cancer, and atherosclerosis-related diseases among the Japanese population

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Interactions between inflammatory gene polymorphisms and HTLV-I infection for total death, incidence of cancer, and atherosclerosis-related diseases among the Japanese population

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