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. 2017 Sep;27(9):420-427.
doi: 10.1016/j.je.2016.08.017. Epub 2017 May 30.

Interactions between inflammatory gene polymorphisms and HTLV-I infection for total death, incidence of cancer, and atherosclerosis-related diseases among the Japanese population

Tara Sefanya Kairupan  1 , Rie Ibusuki  2 , Motahare Kheradmand  3 , Yasuko Sagara  4 , Eva Mariane Mantjoro  5 , Yora Nindita  6 , Hideshi Niimura  7 , Kazuyo Kuwabara  8 , Shin Ogawa  9 , Noriko Tsumematsu-Nakahata  10 , Yasuhito Nerome  11 , Tetsuhiro Owaki  11 , Toshifumi Matsushita  12 , Shigeho Maenohara  13 , Kazunari Yamaguchi  14 , Toshiro Takezaki  15
Affiliations

Interactions between inflammatory gene polymorphisms and HTLV-I infection for total death, incidence of cancer, and atherosclerosis-related diseases among the Japanese population

Tara Sefanya Kairupan et al. J Epidemiol. 2017 Sep.

Abstract

Background: An increased risk of total death owing to human T-lymphotropic virus type-I (HTLV-I) infection has been reported. However, its etiology and protective factors are unclear. Various studies reported fluctuations in immune-inflammatory status among HTLV-I carriers. We conducted a matched cohort study among the general population in an HTLV-I-endemic region of Japan to investigate the interaction between inflammatory gene polymorphisms and HTLV-I infection for total death, incidence of cancer, and atherosclerosis-related diseases.

Method: We selected 2180 sub-cohort subjects aged 35-69 years from the cohort population, after matching for age, sex, and region with HTLV-I seropositives. They were followed up for a maximum of 10 years. Inflammatory gene polymorphisms were selected from TNF-α, IL-10, and NF-κB1. A Cox proportional hazard model was used to estimate the hazard ratio (HR) and the interaction between gene polymorphisms and HTLV-I for risk of total death and incidence of cancer and atherosclerosis-related diseases.

Results: HTLV-I seropositivity rate was 6.4% in the cohort population. The interaction between TNF-α 1031T/C and HTLV-I for atherosclerosis-related disease incidence was statistically significant (p = 0.020). No significant interaction was observed between IL-10 819T/C or NF-κB1 94ATTG ins/del and HTLV-I. An increased HR for total death was observed in the Amami island region, after adjustment of various factors with gene polymorphisms (HR 3.03; 95% confidence interval, 1.18-7.77).

Conclusion: The present study found the interaction between TNF-α 1031T/C and HTLV-I to be a risk factor for atherosclerosis-related disease. Further follow-up is warranted to investigate protective factors against developing diseases among susceptible HTLV-I carriers.

Keywords: Gene polymorphism; HTLV-I; Inflammation; Interaction.

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Figures

Fig. 1
Fig. 1
Flow-chart of the selection process of the sub-cohort subjects. aIncluded 5 death cases. bIncluded 1 death case.
See this image and copyright information in PMC

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