Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2017 Jun 2:2017:bcr2017219747.
doi: 10.1136/bcr-2017-219747.

Insular carcinoma arising on a background of follicular carcinoma, thyrolipomatosis and amyloid goitre

Tze Ling Loh  1 , Sergios Latis  1 , Rohana Bibi Ali  1 , Hemi Patel  1
Affiliations
Case Reports

Insular carcinoma arising on a background of follicular carcinoma, thyrolipomatosis and amyloid goitre

Tze Ling Loh et al. BMJ Case Rep. .

Abstract

A 67-year-old man was referred with a history of a right-sided neck lump and dysphonia, secondary to a lesion in the thyroid gland. After undergoing a total thyroidectomy, he was found to have an exceedingly rare combination of follicular carcinoma, insular carcinoma, thyrolipomatosis and an amyloid goitre in his thyroid gland. He subsequently underwent further radioactive iodine ablation and has been in remission. He was also later incidentally diagnosed with systemic amyloidosis, which explained the amyloid deposition in his thyroid gland.

Keywords: Endocrine cancer; Head and neck cancer; Head and neck surgery; Pathology; Thyroid disease.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Coronal section of the patient’s neck CT scan, demonstrating the large fatty goitre and a solid lesion in the right lobe of the thyroid.
Figure 2
Figure 2
Insular carcinoma completely surrounded by follicular carcinoma.
Figure 3
Figure 3
Close-up of insular carcinoma, showing high mitotic activity and an insular growth pattern.
Figure 4
Figure 4
Close-up of both insular (bottom) and follicular (top) carcinomas.
Figure 5
Figure 5
H+E stained section of the thyroid parenchyma not involved by cancer. Diffuse adipose infiltration of the parenchyma is seen. The yellow arrow shows amyloid protein deposition.
See this image and copyright information in PMC

References

    1. Ge Y, Luna MA, Cowan DF, et al. . Thyrolipoma and thyrolipomatosis: 5 case reports and historical review of the literature. Ann Diagn Pathol 2009;13:384–9. 10.1016/j.anndiagpath.2009.08.003 - DOI - PubMed
    1. Gnepp DR, Ogorzalek JM, Heffess CS. Fat-containing lesions of the thyroid gland. Am J Surg Pathol 1989;13:605–12. 10.1097/00000478-198907000-00009 - DOI - PubMed
    1. Dhayagude RG. Massive fatty infiltration in a colloid goiter. Arch Pathol 1942;33:357–60.
    1. James PD. Amyloid goitre. J Clin Pathol 1972;25:683–8. 10.1136/jcp.25.8.683 - DOI - PMC - PubMed
    1. Nandyala HS, Madapuram S, Yadav M, et al. . Diffuse lipomatosis of the thyroid gland with papillary microcarcinoma: report of a rare entity. Indian J Pathol Microbiol 2015;58:348–50. 10.4103/0377-4929.162890 - DOI - PubMed

Publication types

MeSH terms