The Long-Term Course of Atopic Dermatitis

doi:10.1016/j.det.2017.02.003

Review

. 2017 Jul;35(3):291-297.

doi: 10.1016/j.det.2017.02.003. Epub 2017 Apr 22.

The Long-Term Course of Atopic Dermatitis

Katrina Abuabara¹, David J Margolis², Sinéad M Langan³

Affiliations

¹ Department of Dermatology, University of California San Francisco (UCSF), 2340 Sutter Street, N421, San Francisco, CA 94115, USA. Electronic address: katrina.abuabara@ucsf.edu.
² Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel St, Bloomsbury, London WC1E 7HT, UK.
³ Department of Dermatology, University of Pennsylvania Perelman School of Medicine, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA; Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.

PMID: 28577798
PMCID: PMC5612374
DOI: 10.1016/j.det.2017.02.003

Review

The Long-Term Course of Atopic Dermatitis

Katrina Abuabara et al. Dermatol Clin. 2017 Jul.

. 2017 Jul;35(3):291-297.

doi: 10.1016/j.det.2017.02.003. Epub 2017 Apr 22.

Authors

Katrina Abuabara¹, David J Margolis², Sinéad M Langan³

Affiliations

¹ Department of Dermatology, University of California San Francisco (UCSF), 2340 Sutter Street, N421, San Francisco, CA 94115, USA. Electronic address: katrina.abuabara@ucsf.edu.
² Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel St, Bloomsbury, London WC1E 7HT, UK.
³ Department of Dermatology, University of Pennsylvania Perelman School of Medicine, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA; Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.

PMID: 28577798
PMCID: PMC5612374
DOI: 10.1016/j.det.2017.02.003

Abstract

Atopic dermatitis (AD) is a chronic, relapsing condition, meaning that the intensity of symptoms usually fluctuates over time. Changes in skin physiology may be evident from birth, suggesting that AD may be a lifelong condition marked by intermittent symptoms/disease activity. Methodological considerations for studying the long-term course of AD are reviewed in detail. Improved measurement of the frequency and duration of active disease periods can help to elucidate more about the clinical course AD and the role of treatment in long-term outcomes.

Keywords: Atopic dermatitis; Atopic eczema; Clinical course; Eczema; Epidemiology; Natural history.

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Figures

**Figure 1. Hypothetical example illustrating the long-term course of AD**
Notes: TEWL Transepidermal water loss

See this image and copyright information in PMC

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References

1. Eichenfield LF, Tom WL, Chamlin SL, et al. Guidelines of care for the management of atopic dermatitis: section 1. Diagnosis and assessment of atopic dermatitis. J Am Acad Dermatol. 2014;70(2):338–351. - PMC - PubMed
1. Hanifin JM, R G. Diagnostic features of atopic dermatitis. Acta Derm Venereol. 1980;92(suppl):44–47.
1. Williams HC, W B. Atopic Dermaittis: The epidemiology, causes and prevention of atopic eczema. United Kingdom: Cambridge University Press; 2000. The natural history of atopic dermatitis.
1. Abuabara K, Margolis DJ. Do children really outgrow their eczema, or is there more than one eczema? J Allergy Clin Immunol. 2013;132(5):1139–1140. - PMC - PubMed
1. Hay RJ, Johns NE, Williams HC, et al. The global burden of skin disease in 2010: an analysis of the prevalence and impact of skin conditions. J Invest Dermatol. 2014;134(6):1527–1534. - PubMed

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[1] Eichenfield LF, Tom WL, Chamlin SL, et al. Guidelines of care for the management of atopic dermatitis: section 1. Diagnosis and assessment of atopic dermatitis. J Am Acad Dermatol. 2014;70(2):338–351. - PMC - PubMed

[2] Eichenfield LF, Tom WL, Chamlin SL, et al. Guidelines of care for the management of atopic dermatitis: section 1. Diagnosis and assessment of atopic dermatitis. J Am Acad Dermatol. 2014;70(2):338–351. - PMC - PubMed

[3] Hanifin JM, R G. Diagnostic features of atopic dermatitis. Acta Derm Venereol. 1980;92(suppl):44–47.

[4] Hanifin JM, R G. Diagnostic features of atopic dermatitis. Acta Derm Venereol. 1980;92(suppl):44–47.

[5] Williams HC, W B. Atopic Dermaittis: The epidemiology, causes and prevention of atopic eczema. United Kingdom: Cambridge University Press; 2000. The natural history of atopic dermatitis.

[6] Williams HC, W B. Atopic Dermaittis: The epidemiology, causes and prevention of atopic eczema. United Kingdom: Cambridge University Press; 2000. The natural history of atopic dermatitis.

[7] Abuabara K, Margolis DJ. Do children really outgrow their eczema, or is there more than one eczema? J Allergy Clin Immunol. 2013;132(5):1139–1140. - PMC - PubMed

[8] Abuabara K, Margolis DJ. Do children really outgrow their eczema, or is there more than one eczema? J Allergy Clin Immunol. 2013;132(5):1139–1140. - PMC - PubMed

[9] Hay RJ, Johns NE, Williams HC, et al. The global burden of skin disease in 2010: an analysis of the prevalence and impact of skin conditions. J Invest Dermatol. 2014;134(6):1527–1534. - PubMed

[10] Hay RJ, Johns NE, Williams HC, et al. The global burden of skin disease in 2010: an analysis of the prevalence and impact of skin conditions. J Invest Dermatol. 2014;134(6):1527–1534. - PubMed

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The Long-Term Course of Atopic Dermatitis

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The Long-Term Course of Atopic Dermatitis

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