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. 1985 Mar 16;1(8429):602-4.
doi: 10.1016/s0140-6736(85)92144-0.

Recombinant human interferon alfa-A suppresses HTLV-III replication in vitro

D D Ho, K L Hartshorn, T R Rota, C A Andrews, J C Kaplan, R T Schooley, M S Hirsch

Recombinant human interferon alfa-A suppresses HTLV-III replication in vitro

D D Ho et al. Lancet. .

Abstract

Recombinant human interferon alfa-A (rIFN alpha A) had a dose-related suppressive effect on human T lymphotropic virus type III (HTLV-III) replication in vitro in normal peripheral-blood mononuclear cells (PBMC). Both single-dose and multiple-dose regimens were inhibitory. Such inhibitory concentrations (4-1024 units/ml) were not toxic to PBMC in culture, and were within the ranges achievable in blood after injection. These studies suggest that clinical trials of rIFN alpha A in early HTLV-III infection are warranted.

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