Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Mar 15:8:1178122X17695836.
doi: 10.1177/1178122X17695836. eCollection 2017.

Trends of Dengue Disease Epidemiology

Cucunawangsih  1 , Nata Pratama Hardjo Lugito  2
Affiliations
Review

Trends of Dengue Disease Epidemiology

Cucunawangsih et al. Virology (Auckl). .

Abstract

Dengue disease is an emerging mosquito-borne viral infection transmitted between humans by Aedes spp. that are distributed mainly in the tropical and subtropical region along with chikungunya and zika diseases. The distribution of dengue disease is influenced by local variation, such as geography, rainfall, temperature, and rapid urbanization or migration. The epidemy of mosquito-borne infection significantly led to increased number of cases and hyperendemicity which induce a more severe form of dengue accompanied by cocirculation of chikungunya and zika. The rapid global spreading of dengue disease created public health burdens that are presently unfulfilled by the absence of specific therapy, simple diagnosis tool for the early phase, and effective and efficient vector control system. This review highlights the current situation of dengue distribution, epidemiology, and new strategies for early dengue diagnosis and risk prediction of severity that can be used to improve oversight and alleviate the heavy burden of the disease.

Keywords: Dengue; chikungunya; cocirculation; hyperendemicity; zika.

PubMed Disclaimer

Conflict of interest statement

DECLARATION OF CONFLICTING INTERESTS: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1
Figure 1
Full-length DENV genome and protein organization. The dengue virus open reading frames encode 3 structural proteins: capsid (C), precursor membrane (prM), and envelope (E), with 7 nonstructural (NS) proteins. UTR indicates untranslated region.
Figure 2
Figure 2
Dengue virus cocirculation in the world in the 2000–2013 period.
See this image and copyright information in PMC

References

    1. World Health Organization (WHO) Global Strategy for Dengue Prevention and Control 2012–2020. Geneva, Switzerland: WHO; 2012. pp. 1–43.
    1. Roth A, Mercier A, Lepers C, et al. Concurrent outbreaks of dengue, chikungunya and zika virus infections—an unprecedented epidemic wave of mosquito-borne viruses in the Pacific 2012–2014. [Accessed May 12, 2016];Euro Surveill. 2014 19:20929. http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20929. - PubMed
    1. Musso D, Cao-Lormeau VM, Gubler DJ. Zika virus: following the path of dengue and chikungunya? Lancet. 2005;386:243–244. - PubMed
    1. Simmons CP, Farrar J, Nguyen VVC, et al. Current concepts: dengue. N Engl J Med. 2012;366:1423–1432. - PubMed
    1. Guzman MG, Halstead SB, Artsob H, et al. Dengue: a continuing global threat. Nat Rev Microbiol. 2010;10:S7–S18. - PMC - PubMed

LinkOut - more resources