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. 2017 May 19:13:1373-1384.
doi: 10.2147/NDT.S122739. eCollection 2017.

Developmental and behavioral outcomes of uncomplicated monochorionic diamniotic twins born in the third trimester

Amy Sierakowski  1 , Valsamma Eapen  2   3 , Rudi Črnčec  2   3 , John Smoleniec  4   5
Affiliations

Developmental and behavioral outcomes of uncomplicated monochorionic diamniotic twins born in the third trimester

Amy Sierakowski et al. Neuropsychiatr Dis Treat. .

Abstract

Background: Relatively little is known about the neurodevelopmental and behavioral outcomes of monochorionic diamniotic (MCDA) twin pregnancies where there are no antenatal complications peculiar to monochorionicity or prematurity.

Methods: Twenty-two MCDA twins (44 children) with an average age of 4.3 years, and with no antenatal complications detected by 28 weeks of gestation, were recruited from a feto-maternal unit database. Parents completed a battery of neurodevelopmental and behavioral assessment questionnaires.

Results: Eighteen children (41%) were identified as having developmental or behavioral concerns, predominantly of mild severity, which in turn were associated with a lower birth weight of medium effect size (Cohen's d=0.59).

Conclusion: MCDA twins delivered in the third trimester with no antenatal monochorionic complications in the first two trimesters appear to be at risk for subtle neurodevelopmental difficulties, associated with a lower birth weight. Ongoing developmental surveillance of these children during preschool-age is indicated for early identification and intervention.

Keywords: behavior; diamniotic; long-term outcome; monochorionic; neurodevelopment; twin.

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Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

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