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Review
. 2017 May 2;8(3):346-353.
doi: 10.14336/AD.2016.1021. eCollection 2017 May.

Vitamin D and Chronic Diseases

Hanmin Wang  1   2 , Weiwen Chen  1   2 , Dongqing Li  1   2 , Xiaoe Yin  1   2 , Xiaode Zhang  2 , Nancy Olsen  3 , Song Guo Zheng  2   3
Affiliations
Review

Vitamin D and Chronic Diseases

Hanmin Wang et al. Aging Dis. .

Abstract

Vitamin D is one of the essential nutrients to sustain the human health. As a member of the steroid hormone family, it has a classic role in regulating metabolism of calcium and a non-classic role in affecting cell proliferation and differentiation. Epidemiological studies have shown that 25OHD deficiency is closely associated with common chronic diseases such as bone metabolic disorders, tumors, cardiovascular diseases, and diabetes. 25OHD deficiency is also a risk factor for neuropsychiatric disorders and autoimmune diseases. 25OHD deficiency is highly prevalent in the world. It is therefore necessary to know the adverse health effects of 25OHD deficiency, and to design interventions and early treatments for those who are likely to have low levels of 25OHD.

Keywords: Vitamin D; chronic diseases; deficiency; early prevention.

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References

    1. Holick MF (2004). Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr, 80: 1678s-1688s - PubMed
    1. Mathieu C, Badenhoop K (2005). Vitamin D and type 1 diabetes mellitus: state of the art. Trends Endocrinol Metab, 16: 261-266 - PubMed
    1. Misra M, Pacaud D, Petryk A, Collett-Solberg PF, Kappy M (2008). Vitamin D deficiency in children and its management: review of current knowledge and recommendations. Pediatrics, 122: 398-417 - PubMed
    1. Handono K, Sidarta YO, Pradana BA, Nugroho RA, Hartono IA, Kalim H, et al. (2014). Vitamin D prevents endothelial damage induced by increased neutrophil extracellular traps formation in patients with systemic lupus erythematosus. Acta Med Indones, 46: 189-198 - PubMed
    1. (2015). Correction: Treatment with Vitamin D/MOG Association Suppresses Experimental Autoimmune Encephalomyelitis. PLoS One, 10: e0131260. - PMC - PubMed