Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1985 Jan 28;325(1-2):13-9.
doi: 10.1016/0006-8993(85)90297-5.

Evidence for the presence of 'ouabain like' compound in human cerebrospinal fluid

D Lichtstein, D Minc, A Bourrit, J Deutsch, S J Karlish, H Belmaker, R Rimon, J Palo

Evidence for the presence of 'ouabain like' compound in human cerebrospinal fluid

D Lichtstein et al. Brain Res. .

Abstract

Material extracted and partially purified from human cerebrospinal fluid (CSF) is capable of: a, inhibiting [3H]ouabain binding to rat brain synaptosomes; b, inhibiting the activity of purified pig kidney Na+,K+-ATPase; and c, inhibiting ouabain sensitive induced 86Rb influx to tissue cultured fibroblasts. These results demonstrate the existence of an 'ouabain like' compound (OLC) in human CSF, and are consistent with the hypothesis of the function of this compound as a neuromodulator.

PubMed Disclaimer

Publication types

LinkOut - more resources