Prevalence and risk factors for complications in adult patients with short bowel syndrome receiving long-term home parenteral nutrition
- PMID: 28582806
- DOI: 10.6133/apjcn.082016.08
Prevalence and risk factors for complications in adult patients with short bowel syndrome receiving long-term home parenteral nutrition
Abstract
Background and objectives: Short bowel syndrome (SBS) is a complicated and challenging disease where home parenteral nutrition (HPN) is widely used. The complications of long-term HPN-dependent in adult patients with SBS are poorly documented. This study was mainly aimed to assess the prevalence and risk factors of HPNassociated complications in adult patients with SBS, especially the catheter-related sepsis and HPN-associated liver/biliary disorders.
Methods and study design: 47 non-malignant adult patients with SBS who received HPN for more than 2 years in our clinical nutrition center were included. Patients were divided into two groups according to whether HPN-associated complications were present or not. Student's t-test and χ2 test were applied to compare the differences between the two groups.
Results: The mean frequency of catheter-related sepsis was 0.31±0.05 per catheter year of HPN. An higher incidence of catheter-related infections (p<0.001) and shorter delay between HPN onset and first infection (p<0.001) were identified as risk factors for catheter-related sepsis. A total of 25 patients (53.2%) developed HPN-associated liver/biliary diseases. The identified risk factors for HPNassociated liver/biliary disorders were higher rate of catheter-related infections (p=0.009), shorter delay between HPN onset and first infection (p=0.017), higher energy content of HPN (p=0.014), higher glucose rate of HPN (p=0.009), and lower lipid rate of HPN (p=0.022).
Conclusion: Our study revealed that adult patients with SBS receiving long-term HPN treatment developed a low prevalence of catheter-related sepsis but a rather high prevalence of HPN-associated liver/biliary disorders. We also identified several risk factors for HPN-associated complications which should be taken notice of in clinical practice.
Similar articles
-
Prevalence of life-threatening complications in pediatric patients affected by intestinal failure.Transplant Proc. 2007 Jun;39(5):1632-3. doi: 10.1016/j.transproceed.2007.02.083. Transplant Proc. 2007. PMID: 17580205
-
Clinical outcomes in Crohn's disease patients with short bowel syndrome on home parenteral nutrition are comparable to those with short bowel syndrome from other etiologies.Clin Nutr. 2025 Jun;49:149-156. doi: 10.1016/j.clnu.2025.04.015. Epub 2025 Apr 24. Clin Nutr. 2025. PMID: 40305998
-
[Catheter occlusion and venous thrombosis prevention and incidence in adult home parenteral nutrition (HPN) programme patients].Nutr Hosp. 2012 Jan-Feb;27(1):256-61. doi: 10.1590/S0212-16112012000100033. Nutr Hosp. 2012. PMID: 22566330 Spanish.
-
Clinical, social, and economic impacts of home parenteral nutrition dependence in short bowel syndrome.JPEN J Parenter Enteral Nutr. 2014 May;38(1 Suppl):32S-37S. doi: 10.1177/0148607113517717. Epub 2014 Jan 13. JPEN J Parenter Enteral Nutr. 2014. PMID: 24418898 Review.
-
Parenteral approaches in malabsorption: Home parenteral nutrition.Best Pract Res Clin Gastroenterol. 2016 Apr;30(2):309-18. doi: 10.1016/j.bpg.2016.03.010. Epub 2016 Mar 12. Best Pract Res Clin Gastroenterol. 2016. PMID: 27086893 Review.
Cited by
-
Incidence of catheter-related complications among Japanese patients with central venous catheters as well as patients with short bowel syndrome.Clin Exp Gastroenterol. 2018 Nov 28;11:439-445. doi: 10.2147/CEG.S172430. eCollection 2018. Clin Exp Gastroenterol. 2018. PMID: 30568477 Free PMC article.
-
Comparison of Biochemical and Pathological Parameters and Parenteral Nutrition of ICU Patients Under Supervision of Dietitians and Surgeons.Front Nutr. 2021 Oct 7;8:729510. doi: 10.3389/fnut.2021.729510. eCollection 2021. Front Nutr. 2021. PMID: 34692745 Free PMC article.
-
Short bowel syndrome - experience from a home parenteral nutrition centre.Arch Med Sci. 2021 May 27;17(4):1140-1144. doi: 10.5114/aoms/136344. eCollection 2021. Arch Med Sci. 2021. PMID: 34336046 Free PMC article. No abstract available.
-
Real-world etiologies and treatments of pediatric short bowel syndrome in Japan.Pediatr Int. 2022 Jan;64(1):e15258. doi: 10.1111/ped.15258. Pediatr Int. 2022. PMID: 36163637 Free PMC article.
-
The Long and Short of IT: intestinal failure-associated liver disease (IFALD) in adults-recommendations for early diagnosis and intestinal transplantation.Frontline Gastroenterol. 2020 Jan;11(1):34-39. doi: 10.1136/flgastro-2018-101069. Epub 2019 Feb 12. Frontline Gastroenterol. 2020. PMID: 31885838 Free PMC article. Review.
MeSH terms
LinkOut - more resources
Full Text Sources