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Review
. 2017 Jun 6;8(1):137.
doi: 10.1186/s13287-017-0576-4.

Role of mesenchymal stem cells, their derived factors, and extracellular vesicles in liver failure

Jie Wang  1 , Panpan Cen  1 , Jiajia Chen  1 , Linxiao Fan  1 , Jun Li  1 , Hongcui Cao  1 , Lanjuan Li  2
Affiliations
Review

Role of mesenchymal stem cells, their derived factors, and extracellular vesicles in liver failure

Jie Wang et al. Stem Cell Res Ther. .

Abstract

Liver failure is a severe clinical syndrome with a poor prognosis. Mesenchymal stem cell (MSC) transplantation has emerged as a new intervention in treating liver failure. It is conventionally recognized that MSCs exert their therapeutic effect mainly through transdifferentiation. Recently, published articles have shown that MSCs work in liver failure by secreting trophic and immunomodulatory factors as well as extracellular vesicles (EVs) before transdifferentiation. In particular,MSC-derived EVs have shown similar curative effects as MSCs. Here we review the role of MSCs as well as their derived factors and EVs in liver failure and discuss the use of MSC-derived EVs instead of intact MSCs in treating liver failure.

Keywords: Exosome; Extracellular vesicles; Liver failure; Liver regeneration; Mesenchymal stem cell.

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