Cellular and noncellular bloodborne biomarkers in asthma

Abstract

Objective: To provide an overview of studied cellular and noncellular blood-derived asthma biomarkers.

Data sources: PubMed literature review.

Study selections: Articles discussing cellular and noncellular bloodborne asthma biomarkers.

Results: Discussed asthma biomarkers include peripheral blood cell counts of T cells, fibrocytes, or granulocytes, as well as levels of cytokines, periostin, IgE, and lipid mediators with or without stimulation. Moreover, this article summarizes the association of various blood biomarkers with the type of airway inflammation, presence of atopy, and dominance of specific T-cell subsets and associated pathways in asthma. Furthermore, biomarkers are here listed according to their proposed clinical use, such as diagnosis, disease phenotyping, classification of severity, assessment of disease control, and monitoring of and predicting treatment response.

Conclusion: Further research on asthma biomarkers may improve asthma endotyping and ultimately lead to personalized treatment.