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Review
. 2017 Apr-Jun;17(2):120-127.
doi: 10.4103/jips.jips_62_17.

Demineralized dentin matrix scaffolds for alveolar bone engineering

In-Woong Um  1 , Young-Kyun Kim  2   3 , Masaharu Mitsugi  4
Affiliations
Review

Demineralized dentin matrix scaffolds for alveolar bone engineering

In-Woong Um et al. J Indian Prosthodont Soc. 2017 Apr-Jun.

Abstract

From the point of view of implant dentistry, this review discusses the development and clinical use of demineralized dentin matrix (DDM) scaffolds, produced from the patient's own extracted teeth, to repair alveolar bone defects. The structure and the organic and inorganic components of DDM are presented to emphasize the similarities with autogenous bone. Studies of DDM properties, such as osteoinductive and osteoconductive functions as well as efficacy and safety, which are mandatory for its use as a bone graft substitute, are also presented. The clinical applications of powder, block, and moldable DDM are discussed, along with future developments that can support growth factor and stem cell delivery.

Keywords: Bone graft substitute; demineralized dentin matrix; tooth.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
The common components in dentin and bone. HAP: Hydroxyapatite, OCN: osteocalcin, BMP: bone morphogenetic protein, FGFs: Fibroblast growth factors
Figure 2
Figure 2
Diagrammatic illustration of the transfer of degradation products of radioisotope-labeled dentin matrix
Figure 3
Figure 3
Demineralized dentin matrix powder (300–800 μm) with enlarged dentinal tubules
Figure 4
Figure 4
Demineralized dentin matrix block with macropores (300–400 μm)
Figure 5
Figure 5
Extensive new bone formation around demineralized dentin matrix granules. Asterisks indicate demineralized dentin matrix. Staining by hematoxylin and eosin (×100, magnification)
Figure 6
Figure 6
(a) The defect around the implant, (b) defects are covered by the demineralized dentin matrix particles, (c) texture of newly formed bone after 3 months. Most of the demineralized dentin matrix powder underwent resorption and bone remodeling
Figure 7
Figure 7
(a) The vertical and horizontal alveolar defect around the implant, (b) the defect repaired by the demineralized dentin matrix block and blood clot aggregation, (c) complete formation of corticocancellous bone. Over time, the demineralized dentin matrix block underwent gradual resorption and became less visible
See this image and copyright information in PMC

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