Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Mar-Apr;14(2):104-110.

Salivary oxidative stress in oral lichen planus treated with triamcinolone mouthrinse

Arash Mansourian  1 , Farzaneh Agha-Hosseini  1 , Hamed Hossein Kazemi  2 , Nazanin Mortazavi  3 , Mahdieh-Sadat Moosavi  1 , Jalil Beytollahi  4 , Iraj Mirzaii-Dizgah  5
Affiliations

Salivary oxidative stress in oral lichen planus treated with triamcinolone mouthrinse

Arash Mansourian et al. Dent Res J (Isfahan). 2017 Mar-Apr.

Abstract

Background: Total antioxidant capacity (TAC) and malondialdehyde (MDA) levels have not been reported in oral lichen planus (OLP) patients treated with a topical corticosteroid. This study evaluates TAC and MDA levels in unstimulated saliva of OLP patients. Such measurements may need to be supported by clinical observation.

Materials and methods: Twenty patients with OLP participated in a study conducted at the Department of Oral Medicine, Tehran University of Medical Sciences. Salivary TAC and MDA were determined by biochemical analyses before and after 5-week triamcinolone acetonide (0.2%) mouthrinse treatment. Subjective symptoms as well as lesion status pre- and post-treatment were measured using visual analog scale (VAS) and clinical scoring system, respectively. Wilcoxon signed rank test was used for the evaluation of MDA and TAC parameters, VASs, and rates of clinical scores. Spearman's rank correlation was used to determine the relationship between different variables.

Results: A statistically significant increase in salivary TAC was found after treatment. There was no significant difference in the reduction of salivary MDA levels in OLP patients after treatment.

Conclusion: Posttreatment analyses revealed a significant degree of recovery and pain relief of OLP lesions. Hence, triamcinolon mouthrinse by reducing oxidative stress is an appropriate treatment in OLP patients.

Keywords: Malondialdehyde; oral lichen planus; oxidative stress; triamcinolone acetonide.

PubMed Disclaimer

Conflict of interest statement

The authors of this manuscript declare that they have no conflicts of interest, real or perceived, financial or nonfinancial, in this article.

Figures

Figure 1
Figure 1
Concentration of malondialdehyde in unstimulated saliva of oral lichen planus patients before and after treatment with triamcinolone mouthrinse.
Figure 2
Figure 2
Concentration of total antioxidant capacity in unstimulated saliva of oral lichen planus patients before and after treatment with triamcinolone mouthrinse.
See this image and copyright information in PMC

References

    1. Agha-Hosseini F, Mirzaii-Dizgah I, Farmanbar N, Abdollahi M. Oxidative stress status and DNA damage in saliva of human subjects with oral lichen planus and oral squamous cell carcinoma. J Oral Pathol Med. 2012;41:736–40. - PubMed
    1. van der Waal I. Oral lichen planus and oral lichenoid lesions; a critical appraisal with emphasis on the diagnostic aspects. Med Oral Patol Oral Cir Bucal. 2009;14:E310–4. - PubMed
    1. van der Meij EH, Schepman KP, van der Waal I. The possible premalignant character of oral lichen planus and oral lichenoid lesions: A prospective study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;96:164–71. - PubMed
    1. Gorsky M, Epstein JB. Oral lichen planus: Malignant transformation and human papilloma virus: A review of potential clinical implications. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;111:461–4. - PubMed
    1. Arana C, Cutando A, Ferrera MJ, Gómez-Moreno G, Worf CV, Bolaños MJ, et al. Parameters of oxidative stress in saliva from diabetic and parenteral drug addict patients. J Oral Pathol Med. 2006;35:554–9. - PubMed

LinkOut - more resources