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Case Reports
. 2017:2017:7031414.
doi: 10.1155/2017/7031414. Epub 2017 May 11.

Hybrid Desmoplastic/Follicular Ameloblastoma of the Mandible: A Case Report and Review of the Literature

Masayasu Iwase  1 , Airi Fukuoka  2 , Yoko Tanaka  2 , Naoyuki Saida  2 , Eriko Onaka  1 , Sanae Bando  1 , Gen Kondo  3
Affiliations
Case Reports

Hybrid Desmoplastic/Follicular Ameloblastoma of the Mandible: A Case Report and Review of the Literature

Masayasu Iwase et al. Case Rep Pathol. 2017.

Abstract

Desmoplastic ameloblastoma (DA) is one of the 6 histopathological subtypes of ameloblastoma. Hybrid lesions in which histopathologically conventional ameloblastoma coexists with areas of DA are rare. A 40-year-old male was referred to our hospital complaining of a swelling in the right premolar region of the mandible. A panoramic radiograph showed an area of radiolucency with a well-defined corticated border, whereas computed tomography revealed a unilocular radiolucent lesion and buccal expansion together with cortical perforation. The lesion was treated via enucleation and curettage of the marginal bone and fenestration. A histopathological examination showed a hybrid ameloblastoma with a pronounced desmoplastic pattern and follicular changes. The patient's postoperative course has been favorable up to now, and no marked changes have been observed. We presented a case of hybrid ameloblastoma and reviewed the 36 reported cases of hybrid ameloblastoma that have been reported in the English literature.

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Figures

Figure 1
Figure 1
An image of the oral cavity obtained during the initial examination showing a painless mass in the lower right premolar region.
Figure 2
Figure 2
A panoramic radiograph showing a well-defined large radiolucent lesion in the right mandible.
Figure 3
Figure 3
(a) Axial and (b) coronal computed tomography scans showing a large unilocular radiolucent lesion in the right mandible.
Figure 4
Figure 4
The surgical specimen had a gourd-like shape, and its cross section contained a solid portion and a cystic lesion (arrow).
Figure 5
Figure 5
(a) A histopathological image showing a mixture of follicular and desmoplastic ameloblastoma. (×10) (b) A histopathological image showing stellate-shaped epithelial islands together with squamous metaplasia in the collagenized fibrous stroma containing connective tissue. (×40) (c) A histopathological image showing typical follicular ameloblastoma together with cystic degeneration and squamous metaplasia (×40).
Figure 6
Figure 6
(a) A panoramic radiograph obtained just after the operation showing a well-defined large unilocular radiolucent lesion in the right mandible. (b) A panoramic radiograph and (c) axial and (d) coronal computed tomography obtained at 22 postoperative months showing that the radiopaque area had increased in size.
See this image and copyright information in PMC

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