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Review
. 2017 Oct;31(5):764-778.
doi: 10.1007/s00540-017-2375-6. Epub 2017 Jun 5.

A clinical review of inhalation anesthesia with sevoflurane: from early research to emerging topics

Jorge D Brioni  1 , Shane Varughese  2 , Raza Ahmed  2 , Berthold Bein  3
Affiliations
Review

A clinical review of inhalation anesthesia with sevoflurane: from early research to emerging topics

Jorge D Brioni et al. J Anesth. 2017 Oct.

Abstract

A large number of studies during the past two decades have demonstrated the efficacy and safety of sevoflurane across patient populations. Clinical researchers have also investigated the effects of sevoflurane, its hemodynamic characteristics, its potential protective effects on several organ systems, and the incidence of delirium and cognitive deficiency. This review examines the clinical profiles of sevoflurane and other anesthetic agents, and focuses upon emerging topics such as organ protection, postoperative cognitive deficiency and delirium, and novel ways to improve postanesthesia outcomes.

Keywords: Cardiac protection; Delirium; Emergence; Postoperative cognitive dysfunction; Volatile anesthetic.

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Conflict of interest statement

Prof. Dr. Berthold Bein has received unrestricted research grants, honoraria for lectures, and consulting fees from AbbVie Germany, the manufacturer of sevoflurane; honoraria for lectures from Baxter Healthcare, the manufacturer of desflurane; and honoraria for lectures from GlaxoSmithKline, the manufacturer of propofol. Jorge Brioni, Ph.D., Shane Varughese, M.D., and Raza Ahmed, M.D. are employees of AbbVie and may hold AbbVie stock or options. AbbVie participated in the writing, reviewing, and approval of this publication. No payments were made to the authors for the development of this manuscript, and all authors approved the final version.

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