Tree shrew (Tupaia belangeri) as a novel laboratory disease animal model

doi:10.24272/j.issn.2095-8137.2017.033

Review

. 2017 May 18;38(3):127-137.

doi: 10.24272/j.issn.2095-8137.2017.033.

Tree shrew (Tupaia belangeri) as a novel laboratory disease animal model

Ji Xiao¹, Rong Liu², Ce-Shi Chen³

Affiliations

¹ Medical Faculty of Kunming University of Science and Technology, Kunming Yunnan 650500, China; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, China.
² Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, China.
³ Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, China. chenc@mail.kiz.ac.cn.

PMID: 28585436
PMCID: PMC5460081
DOI: 10.24272/j.issn.2095-8137.2017.033

Review

Tree shrew (Tupaia belangeri) as a novel laboratory disease animal model

Ji Xiao et al. Zool Res. 2017.

. 2017 May 18;38(3):127-137.

doi: 10.24272/j.issn.2095-8137.2017.033.

Authors

Ji Xiao¹, Rong Liu², Ce-Shi Chen³

Affiliations

¹ Medical Faculty of Kunming University of Science and Technology, Kunming Yunnan 650500, China; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, China.
² Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, China.
³ Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, China. chenc@mail.kiz.ac.cn.

PMID: 28585436
PMCID: PMC5460081
DOI: 10.24272/j.issn.2095-8137.2017.033

Abstract

The tree shrew (Tupaia belangeri) is a promising laboratory animal that possesses a closer genetic relationship to primates than to rodents. In addition, advantages such as small size, easy breeding, and rapid reproduction make the tree shrew an ideal subject for the study of human disease. Numerous tree shrew disease models have been generated in biological and medical studies in recent years. Here we summarize current tree shrew disease models, including models of infectious diseases, cancers, depressive disorders, drug addiction, myopia, metabolic diseases, and immune-related diseases. With the success of tree shrew transgenic technology, this species will be increasingly used in biological and medical studies in the future.

Keywords: Animal model; Disease; Transgenic; Tree shrew (Tupaia belangeri).

PubMed Disclaimer

Cited by

Breast cancer animal models and applications.
Zeng L, Li W, Chen CS. Zeng L, et al. Zool Res. 2020 Sep 18;41(5):477-494. doi: 10.24272/j.issn.2095-8137.2020.095. Zool Res. 2020. PMID: 32629551 Free PMC article. Review.
The characteristics of gut microbiota and commensal Enterobacteriaceae isolates in tree shrew (Tupaia belangeri).
Gu W, Tong P, Liu C, Wang W, Lu C, Han Y, Sun X, Kuang X, Li N, Dai J. Gu W, et al. BMC Microbiol. 2019 Sep 2;19(1):203. doi: 10.1186/s12866-019-1581-9. BMC Microbiol. 2019. PMID: 31477004 Free PMC article.
Neural Progenitors in the Developing Neocortex of the Northern Tree Shrew (Tupaia belangeri) Show a Closer Relationship to Gyrencephalic Primates Than to Lissencephalic Rodents.
Römer S, Bender H, Knabe W, Zimmermann E, Rübsamen R, Seeger J, Fietz SA. Römer S, et al. Front Neuroanat. 2018 Apr 19;12:29. doi: 10.3389/fnana.2018.00029. eCollection 2018. Front Neuroanat. 2018. PMID: 29725291 Free PMC article.
Cognitive Deficits and Alzheimer's Disease-Like Pathologies in the Aged Chinese Tree Shrew.
Li H, Xiang BL, Li X, Li C, Li Y, Miao Y, Ma GL, Ma YH, Chen JQ, Zhang QY, Lv LB, Zheng P, Bi R, Yao YG. Li H, et al. Mol Neurobiol. 2024 Apr;61(4):1892-1906. doi: 10.1007/s12035-023-03663-7. Epub 2023 Oct 9. Mol Neurobiol. 2024. PMID: 37814108
Morphology, genetic characterization and phylogeny of Moniliformis tupaia n. sp. (Acanthocephala: Moniliformidae) from the northern tree shrew Tupaia belangeri chinensis Anderson (Mammalia: Scandentia).
Chen HX, Yu ZJ, Ma J, Zhao CH, Cao FQ, Li L. Chen HX, et al. Parasitology. 2024 Apr;151(4):440-448. doi: 10.1017/S0031182024000271. Epub 2024 Mar 4. Parasitology. 2024. PMID: 38525532 Free PMC article.

See all "Cited by" articles

References

1. Ábrahám H, Czéh B, Fuchs E, Seress L. 2005. Mossy cells and different subpopulations of pyramidal neurons are immunoreactive for cocaine-and amphetamine-regulated transcript peptide in the hippocampal formation of non-human primates and tree shrew (Tupaia belangeri). Neuroscience, 136 (1): 231-240. - PubMed
1. Amako Y, Tsukiyama-Kohara K, Katsume A, Hirata Y, Sekiguchi S, Tobita Y, Hayashi Y, Hishima T, Funata N, Yonekawa H, Kohara M. 2010. Pathogenesis of hepatitis C virus infection in Tupaia belangeri. Journal of Virology, 84 (1): 303-311. - PMC - PubMed
1. Brack M, Schwartz P, Heinrichs T, Schultz M, Fuchs E. 1996. Tumors of the respiratory tract observed at the German Primate Center, 1978-1994. Journal of Medical Primatology, 25 (6): 424-434. - PubMed
1. Buchholz DR. 2015. More similar than you think:frog metamorphosis as a model of human perinatal endocrinology. Developmental Biology, 408 (2): 188-195. - PubMed
1. Capecchi MR. 2005. Gene targeting in mice:functional analysis of the mammalian genome for the twenty-first century. Nature Reviews Genetics, 6 (6): 507-512. - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations

[1] Ábrahám H, Czéh B, Fuchs E, Seress L. 2005. Mossy cells and different subpopulations of pyramidal neurons are immunoreactive for cocaine-and amphetamine-regulated transcript peptide in the hippocampal formation of non-human primates and tree shrew (Tupaia belangeri). Neuroscience, 136 (1): 231-240. - PubMed

[2] Ábrahám H, Czéh B, Fuchs E, Seress L. 2005. Mossy cells and different subpopulations of pyramidal neurons are immunoreactive for cocaine-and amphetamine-regulated transcript peptide in the hippocampal formation of non-human primates and tree shrew (Tupaia belangeri). Neuroscience, 136 (1): 231-240. - PubMed

[3] Amako Y, Tsukiyama-Kohara K, Katsume A, Hirata Y, Sekiguchi S, Tobita Y, Hayashi Y, Hishima T, Funata N, Yonekawa H, Kohara M. 2010. Pathogenesis of hepatitis C virus infection in Tupaia belangeri. Journal of Virology, 84 (1): 303-311. - PMC - PubMed

[4] Amako Y, Tsukiyama-Kohara K, Katsume A, Hirata Y, Sekiguchi S, Tobita Y, Hayashi Y, Hishima T, Funata N, Yonekawa H, Kohara M. 2010. Pathogenesis of hepatitis C virus infection in Tupaia belangeri. Journal of Virology, 84 (1): 303-311. - PMC - PubMed

[5] Brack M, Schwartz P, Heinrichs T, Schultz M, Fuchs E. 1996. Tumors of the respiratory tract observed at the German Primate Center, 1978-1994. Journal of Medical Primatology, 25 (6): 424-434. - PubMed

[6] Brack M, Schwartz P, Heinrichs T, Schultz M, Fuchs E. 1996. Tumors of the respiratory tract observed at the German Primate Center, 1978-1994. Journal of Medical Primatology, 25 (6): 424-434. - PubMed

[7] Buchholz DR. 2015. More similar than you think:frog metamorphosis as a model of human perinatal endocrinology. Developmental Biology, 408 (2): 188-195. - PubMed

[8] Buchholz DR. 2015. More similar than you think:frog metamorphosis as a model of human perinatal endocrinology. Developmental Biology, 408 (2): 188-195. - PubMed

[9] Capecchi MR. 2005. Gene targeting in mice:functional analysis of the mammalian genome for the twenty-first century. Nature Reviews Genetics, 6 (6): 507-512. - PubMed

[10] Capecchi MR. 2005. Gene targeting in mice:functional analysis of the mammalian genome for the twenty-first century. Nature Reviews Genetics, 6 (6): 507-512. - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Tree shrew (Tupaia belangeri) as a novel laboratory disease animal model

Affiliations

Tree shrew (Tupaia belangeri) as a novel laboratory disease animal model

Authors

Affiliations

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

Related information

LinkOut - more resources

Full Text Sources

Other Literature Sources