doi: 10.1111/j.2042-7158.1985.tb05044.x.
Effect of verapamil and diltiazem on isolated gastro-oesophageal sphincter of the rat
- PMID: 2858571
- DOI: 10.1111/j.2042-7158.1985.tb05044.x
Item in Clipboard
Effect of verapamil and diltiazem on isolated gastro-oesophageal sphincter of the rat
J Pharm Pharmacol.
1985 Mar.
Abstract
The effect of verapamil and diltiazem on the contraction induced by agonists on the rat lower oesophageal sphincter in-vitro has been studied. Both calcium entry blockers inhibited the contractile response to acetylcholine, carbachol and KCl. The potency of the inhibitory action was diltiazem greater than verapamil. The results give substance to the use of calcium entry blockers in the treatment of oesophageal spasm.
Similar articles
-
Effects of the calcium antagonists diltiazem, verapamil and nitrendipine on the contractile responses of guinea-pig isolated ileum to electrical stimulation or carbachol.J Pharm Pharmacol. 1992 Apr;44(4):321-5. doi: 10.1111/j.2042-7158.1992.tb03614.x. J Pharm Pharmacol. 1992. PMID: 1355544
-
Inhibitory effects of various L-type and T-type calcium antagonists on electrically generated, potassium-induced and carbachol-induced contractions of porcine detrusor muscle.J Comp Physiol B. 2006 Jun;176(5):429-39. doi: 10.1007/s00360-006-0064-0. Epub 2006 Jan 20. J Comp Physiol B. 2006. PMID: 16425017
-
Antagonistic activity of verapamil and diltiazem against different intestinal smooth muscle stimuli.Arzneimittelforschung. 1984;34(2):181-4. Arzneimittelforschung. 1984. PMID: 6539111
-
Calcium-channel blocking agents.Clin Pharm. 1982 Jan-Feb;1(1):17-33. Clin Pharm. 1982. PMID: 6764159 Review.
-
Some extracardiac effects of diltiazem and other calcium entry blockers.Acta Pharmacol Toxicol (Copenh). 1985;57 Suppl 2:31-43. doi: 10.1111/j.1600-0773.1985.tb03572.x. Acta Pharmacol Toxicol (Copenh). 1985. PMID: 3904331 Review.
Cited by
-
Comparison of observational and controlled clinical trials of diltiazem in the treatment of chronic anal fissure.Indian J Surg. 2011 Dec;73(6):427-31. doi: 10.1007/s12262-011-0340-4. Epub 2011 Oct 18. Indian J Surg. 2011. PMID: 23204700 Free PMC article.
-
Topical diltiazem and bethanechol decrease anal sphincter pressure without side effects.Gut. 1999 Nov;45(5):719-22. doi: 10.1136/gut.45.5.719. Gut. 1999. PMID: 10517908 Free PMC article. Clinical Trial.
-
Effects of calcium channel blockers on gastric emptying and acid secretion of the rat in vivo.Br J Pharmacol. 1986 Dec;89(4):627-33. doi: 10.1111/j.1476-5381.1986.tb11166.x. Br J Pharmacol. 1986. PMID: 3814903 Free PMC article.
-
Tetrodotoxin-sensitive and -insensitive relaxations in the rat oesophageal tunica muscularis mucosae.J Physiol. 1986 Dec;381:49-63. doi: 10.1113/jphysiol.1986.sp016312. J Physiol. 1986. PMID: 3114474 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
