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Review
. 2017 Jul 1;43(4):706-711.
doi: 10.1093/schbul/sbx065.

Preclinical Models to Investigate Mechanisms of Negative Symptoms in Schizophrenia

Samuel A Barnes  1 , Andre Der-Avakian  1 , Jared W Young  1   2
Affiliations
Review

Preclinical Models to Investigate Mechanisms of Negative Symptoms in Schizophrenia

Samuel A Barnes et al. Schizophr Bull. .
No abstract available

Keywords: decision making; effort; mice; rats; reward.

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Figures

Fig. 1.
Fig. 1.
Subdomains contributing to effort-based decision making. Effort-based decision making is a critical component of negative symptoms in schizophrenia and can be readily assessed in humans and rodents. Further, subdomains are identified whose neural mechanisms can be investigated in rodent studies. Dopamine D1 receptors have been implicated in each aspect of decision making, while dopamine D2 receptors contribute toward physical effort and reward-associative learning. Both cannabinoid CB1 and α7 nicotinic acetylcholine receptors have been implicated in reward associative learning, while CB1 receptors may also drive cognitive effortful motivation.
See this image and copyright information in PMC

References

    1. Strauss GP, Cohen AS. A transdiagnoostic review of negative symptom phenomonology and etiology. Schizophr Bull. In press. - PMC - PubMed
    1. Rassovsky Y, Horan WP, Lee J, Sergi MJ, Green MF. Pathways between early visual processing and functional outcome in schizophrenia. Psychol Med. 2011;41:487–497. - PMC - PubMed
    1. Horan WP, Kring AM, Blanchard JJ. Anhedonia in schizophrenia: a review of assessment strategies. Schizophr Bull. 2006;32:259–273. - PMC - PubMed
    1. Green MF, Hellemann G, Horan WP, Lee J, Wynn JK. From perception to functional outcome in schizophrenia: modeling the role of ability and motivation. Arch Gen Psychiatry. 2012;69:1216–1224. - PMC - PubMed
    1. Der-Avakian A, D’Souza MS, Pizzagalli DA, Markou A. Assessment of reward responsiveness in the response bias probabilistic reward task in rats: implications for cross-species translational research. Transl Psychiatry. 2013;3:e297. - PMC - PubMed

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