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Comment
. 2017 Jun 5;41(5):451-452.
doi: 10.1016/j.devcel.2017.05.015.

The Bony Side of Endothelial Cells in Prostate Cancer

Jia Peng  1 , Yibin Kang  2
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Free article
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The Bony Side of Endothelial Cells in Prostate Cancer

Jia Peng et al. Dev Cell. .
Free article

Abstract

Prostate cancer bone metastases are primarily osteoblastic, but the source of bone-forming cells in these lesions remains poorly defined. In this issue of Developmental Cell, Lin et al. (2017) demonstrate that tumor-associated endothelial cells can give rise to osteoblasts in prostate cancer through endothelial-to-osteoblast (EC-to-OSB) conversion.

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