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Comment
. 2017 Jun 5;41(5):456-458.
doi: 10.1016/j.devcel.2017.05.018.

R-spondin Is More Than Just Wnt's Sidekick

David J Huels  1 , Owen J Sansom  2
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Free article
Comment

R-spondin Is More Than Just Wnt's Sidekick

David J Huels et al. Dev Cell. .
Free article

Abstract

The intestinal crypt and its stem cells are dependent on the Wnt pathway. Reporting in Nature, Yan et al. (2017) show that Wnts and Wnt signaling potentiator R-spondins have non-interchangeable roles. Both are necessary for intestinal stem cell (ISC) maintenance, and R-spondins are the limiting factor that defines ISC number.

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  • Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal.
    Yan KS, Janda CY, Chang J, Zheng GXY, Larkin KA, Luca VC, Chia LA, Mah AT, Han A, Terry JM, Ootani A, Roelf K, Lee M, Yuan J, Li X, Bolen CR, Wilhelmy J, Davies PS, Ueno H, von Furstenberg RJ, Belgrader P, Ziraldo SB, Ordonez H, Henning SJ, Wong MH, Snyder MP, Weissman IL, Hsueh AJ, Mikkelsen TS, Garcia KC, Kuo CJ. Yan KS, et al. Nature. 2017 May 11;545(7653):238-242. doi: 10.1038/nature22313. Epub 2017 May 3. Nature. 2017. PMID: 28467820 Free PMC article.

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