Nerve Growth Factor and Related Substances: A Brief History and an Introduction to the International NGF Meeting Series

Abstract

Nerve growth factor (NGF) is a protein whose importance to research and its elucidation of fundamental mechanisms in cell and neurobiology far outstrips its basic physiological roles. It was the first of a broad class of cell regulators, largely acting through autocrine and paracrine interactions which will be described herein. It was of similar significance in establishing the identity and unique roles of neurotrophic factors in the development and maintenance of the peripheral and central nervous systems. Finally, it contributed to many advances in the elaboration of cell surface receptor mechanisms and intracellular cell signaling. As such, it can be considered to be a "molecular Rosetta Stone". In this brief review, the highlights of these various studies are summarized, particularly as illustrated by their coverage in the 13 NGF international meetings that have been held since 1986.

Keywords: cell signaling; central nervous system; devleopment; growth factors; neurotrophins; receptors.

Figure 1

Nerve growth factor (NGF) “Halo” effect on cultured peripheral ganglia.

Figure 2

(A) Registration desk in Monterey for the 1st NGF conference held in 1986; and (B) Honoree, Rita Levi-Montalcini.

Figure 3

Crystal structure of NGF [45]. Shown at the 2nd NGF conference held in 1991.

Figure 4

List of all NGF conferences held over 30 years 1986–2016.

Figure 5

List of the complete 13 conferences in the NGF and Related Molecules series, 1986–2016, organizing committees and venue.

Figure 6

Characteristics that have made the NGF Conference series unique.

Figure 7

Attendees at the 13th NGF and Related Factors Conference, 30th ReUnion held in Monterey, April 2016.