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Review
. 2017 Jun 6;6(2):12.
doi: 10.3390/antibiotics6020012.

Bacteria from Animals as a Pool of Antimicrobial Resistance Genes

Maria Angeles Argudín  1 , Ariane Deplano  2 , Alaeddine Meghraoui  3 , Magali Dodémont  4 , Amelie Heinrichs  5 , Olivier Denis  6   7 , Claire Nonhoff  8 , Sandrine Roisin  9
Affiliations
Review

Bacteria from Animals as a Pool of Antimicrobial Resistance Genes

Maria Angeles Argudín et al. Antibiotics (Basel). .

Abstract

Antimicrobial agents are used in both veterinary and human medicine. The intensive use of antimicrobials in animals may promote the fixation of antimicrobial resistance genes in bacteria, which may be zoonotic or capable to transfer these genes to human-adapted pathogens or to human gut microbiota via direct contact, food or the environment. This review summarizes the current knowledge of the use of antimicrobial agents in animal health and explores the role of bacteria from animals as a pool of antimicrobial resistance genes for human bacteria. This review focused in relevant examples within the ESC(K)APE (Enterococcus faecium, Staphylococcus aureus, Clostridium difficile (Klebsiella pneumoniae), Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacteriaceae) group of bacterial pathogens that are the leading cause of nosocomial infections throughout the world.

Keywords: cfr; mcr; mec.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Interactions between groups. Antimicrobial-resistant bacteria can spread to humans either by the food supply, direct contact with food or companion animals or, more indirectly, through environmental pathways, including waterways, soils and vegetables contaminated with human or animals waste, and vectors such as rodents, insects, and birds. Based on da Costa et al. [8] and McEwen et al. [9] with modifications.
See this image and copyright information in PMC

References

    1. Butaye P., Argudín M.A., Threlfall J. Introduction to antimicrobial-resistant foodborne pathogens. In: Chen C.Y., Yan X., Jackson C.R., editors. Antimicrobial Resistance and Food Safety: Methods and Techniques. 1st ed. Academic Press; Cambridge, MA, USA: 2015. pp. 1–18.
    1. O’Neill J. Tackling Drug-Resistant Infections Globally: Final Report and Recommendations. The Review on Antimicrobial Resistance. HM Government and the Wellcome Trust; London, UK: 2016. [(accessed on 27 March 2017)]. Available online: https://amr-review.org/sites/default/files/160518_Final%20paper_with%20c....
    1. Woolhouse M., Ward M., van Bunnik B., Farrar J. Antimicrobial resistance in humans, livestock and the wider environment. Philos Trans. R. Soc. Lond. Ser. B Biol. Sci. 2015;370:20140083. doi: 10.1098/rstb.2014.0083. - DOI - PMC - PubMed
    1. Rice L.B. Federal funding for the study of antimicrobial resistance in nosocomial pathogens: No ESKAPE. J. Infect. Dis. 2008;197:1079–1081. doi: 10.1086/533452. - DOI - PubMed
    1. De Rosa F.G., Corcione S., Pagani N., Di Perri G. From ESKAPE to ESCAPE, from KPC to CCC. Clin. Infect. Dis. 2015;60:1289–1290. doi: 10.1093/cid/ciu1170. - DOI - PubMed

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