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. 2017 Jun;13(6):2616-2622.
doi: 10.3892/etm.2017.4331. Epub 2017 Apr 12.

Clinical evaluation of CENP-B and Scl-70 autoantibodies in silicosis patients

Suni Lee  1 , Hiroaki Hayashi  2 , Naoko Kumagai-Takei  1 , Hidenori Matsuzaki  1 , Kei Yoshitome  1 , Yasumitsu Nishimura  1 , Kozo Uragami  3 , Masayasu Kusaka  4 , Shoko Yamamoto  1 , Miho Ikeda  1 , Tamayo Hatayama  1 , Wataru Fujimoto  2 , Takemi Otsuki  1
Affiliations

Clinical evaluation of CENP-B and Scl-70 autoantibodies in silicosis patients

Suni Lee et al. Exp Ther Med. 2017 Jun.

Abstract

Silicosis patients (SIL) suffer from respiratory disorders and dysregulation of autoimmunity. Frequent complications such as rheumatoid arthritis, systemic sclerosis (SSc) and vasculitis are known in SIL. Furthermore, we reported previously that some SIL exhibited better respiratory conditions in association with a worse immunological status. In this study, the clinical roles of anti-CENP-B and Scl-70 autoantibodies in SIL were analyzed. The titer index (Log10) of anti-CENP-B autoantibody in SIL was higher than that of healthy volunteers (HV), and that of SSc was higher than those of HV and SIL. This titer index was positively correlated with an assumed immune status of 1 for HV, 2 for SIL, and 3 for SSc. Moreover, although factor analysis revealed that the titer index of the anti-CENP-B autoantibody formed the same factor with the anti-Scl-70 autoantibody, IgG value and age in SIL cases, another extracted factor indicated that the IgA value and anti-Scl-70 antibody were positively related, but anti-CENP-B showed an opposite pattern in the results of the factor analysis. These findings indicated that the titer index of anti-CENP-B autoantibody may be a biomarker for dysregulation in SIL cases. Future clinical follow-up of SIL may therefore require both respiratory and immunological assessment.

Keywords: CENP-B autoantibody; Scl-70 autoantibody; silicosis; systemic sclerosis.

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Figures

Figure 1.
Figure 1.
Comparison of titer indices (Log10) and actual indices (in blue) of (A) anti-CENP-B and (B) anti-Scl-70 autoantibodies in healthy volunteers (HV), silicosis patients (SIL) and systemic sclerosis patients (SSc). Statistical comparisons used the non-parametric Kruskal-Wallis test.
Figure 2.
Figure 2.
Correlation between titer indices (Log10) and actual indices (in blue) of (A) anti-CENP-B and (B) anti-Scl-70 autoantibodies and the assumed immune status of 1, 2 and 3 for HV, SIL and SSc, respectively, as the continuous variables. Statistical comparisons used the non-parametric Spearman's test.
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